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:: Volume 16, Issue 5 (1-2015) ::
2015, 16(5): 319-328 Back to browse issues page
Effect of Legumes Intake on the Oxidative Stress Markers in Type 2 Diabetes Patients: A Randomized Cross-over Study
Ensieh Fallah noroozinejad, Somaye Hosseinpour niazi, Parvin Mirmiran, Mehdi Hedayati, Hossein Delshad
shahid beheshti medical university of medical science , mirmiran@endocrine.ac.ir
Abstract:   (8450 Views)

Introduction: Oxidative stress plays a key role in the pathogenesis of late diabetic complications, the markers of which could be improved by the beneficial effects of legumes. Materials and Methods: In this randomized crossover trial, 24 overweight subjects, aged 50-80 years, with type 2 diabetes, were selected. We aimed to determine the effects of non-soybean legumes consumption on oxidative stress markers such as ox-LDL (oxidative LDL), MDA (Malonedialdehyde) and TAC (total antioxidant capacity) in type 2 diabetic patients. The subjects were randomly assigned into two groups, receiving two diets – the TLC (controls) or the TLC diet with legumes (receiving 2 servings of legumes instead of meat three days of the week in the TLC diet). Duration of each diet was 8 weeks with a 4 week wash-out period. At the beginning and end of each dietary period, fasting plasma glucose, ox-LDL, MDA, TAC and weight were measured. Results: After the nutritional intervention, diabetic patients, those individuals who followed the legume-based TLC diet had significant reduction in ox- LDL (-3.1±0.5 vs. -0.7±0.4 P=0.003) and MDA (-1.1±0.2 vs. -0.3±0.1 P=0.006),  but no change was observed in the TAC and BMI of the case and control groups. Conclusions: The legume-based TLC diet improves oxidative stress markers in diabetic patients, compared to the legume-free TLC diet. 

Keywords: Type 2 diabetes, Legumes, oxidative LDL, Malonedialdehyde, Total antioxidant capacity
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Type of Study: Original | Subject: Nutrition
Received: 2014/07/22 | Accepted: 2014/11/19 | Published: 2015/01/11
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fallah noroozinejad E, hosseinpour niazi S, Mirmiran P, hedayati M, delshad H. Effect of Legumes Intake on the Oxidative Stress Markers in Type 2 Diabetes Patients: A Randomized Cross-over Study. Iranian Journal of Endocrinology and Metabolism 2015; 16 (5) :319-328
URL: http://ijem.sbmu.ac.ir/article-1-1769-en.html

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Volume 16, Issue 5 (1-2015) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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