Iranian Journal of Endocrinology and Metabolism
مجلهي غدد درونريز و متابوليسم ايران
Iranian Journal of Endocrinology and Metabolism
Medical Sciences
http://ijem.sbmu.ac.ir
40
journal40
1683-4844
1683-5476
fa
jalali
1393
10
1
gregorian
2015
1
1
16
5
online
1
fulltext
fa
بررسی اثر دریافت حبوبات بر شاخصهای استرس اکسیداتیو در بیماران مبتلا به دیابت نوع 2 (کارآزمایی بالینی تصادفی متقاطع)
Effect of Legumes Intake on the Oxidative Stress Markers in Type 2 Diabetes Patients: A Randomized Cross-over Study
تغذيه
Nutrition
پژوهشی
Original
<p class="Abstract" dir="rtl" style="margin-right: 36pt text-indent: 3.7pt line-height: 16pt"><u><span lang="FA" style="font-size: 11pt font-family: Lotus">مقدمه</span></u><span lang="FA" style="font-size: 11pt font-family: Lotus">: استرس اکسیداتیو نقش مهمی در
بیماریزایی و عوارض دیابت دارد. از طرفی مصرف حبوبات میتواند اثرات مفیدی بر
بهبود شاخصهای استرس اکسیداتیو در بیماران مبتلا به دیابت داشته باشد. هدف پژوهش
حاضر، تعیین اثر دریافت حبوبات غیر سویا روی شاخصهای استرس اکسیداتیو، مانند </span><span dir="ltr">LDL</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>
اکسید شده (</span><span dir="ltr">ox-LDL</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>)، مالوندیآلدئید (</span><span dir="ltr">MDA</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>) و ظرفیت
تام آنتیاکسیدانی (</span><span dir="ltr">TAC</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>) در این بیماران بود.</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span> <u>مواد</u></span><span dir="ltr"></span><span dir="ltr"></span><u><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></u><u><span lang="FA" style="font-size: 11pt font-family: Lotus">و</span></u><span dir="ltr"></span><span dir="ltr"></span><u><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span></u><u><span lang="FA" style="font-size: 11pt font-family: Lotus">روشها</span></u><span lang="FA" style="font-size: 11pt font-family: Lotus">:</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">در</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">این</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">کارآزمایی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">بالینی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">تصادفی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">متقاطع،</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>24</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">فرد
مبتلا</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">به</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">دیابت</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">نوع
2 و</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">دارای اضافه وزن،</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">در</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">دامنهی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">سنی80-50 سال،</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">انتخاب
شدند. افراد به طور</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">تصادفی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">به</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">دو</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">گروه</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">دریافت</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">کنندهی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">رژیم</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">غذایی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">بر</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">پایهی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">تغییرات</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">درمانی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">شیوهی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">زندگی
(کنترل) و</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">یا دریافت کنندهی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">رژیم</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">غذایی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">بر</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">پایهی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">تغییرات</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">درمانی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">شیوهی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">زندگی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">به
همراه</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">حبوبات (جایگزینی2 واحد</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">حبوبات</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">در</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">سه</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">روز</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">هفته</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">به</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">جای</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">واحد</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">گوشت</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">دریافتی)
تقسیم</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">شدند.</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">طول</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">هر یک</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">از</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">رژیمها</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>8</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">هفته</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">بود</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">که</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">با</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">یک</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">دوره</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">شستشوی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>4</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">هفتهای</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">از</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">هم</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">جدا</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">میشدند. ابتدا</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">و</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">انتهای</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">هر</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">دو</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">مرحلهی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">دریافت</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">رژیم</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">غذایی</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">گلوکز</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>
</span><span lang="FA" style="font-size: 11pt font-family: Lotus">ناشتای</span><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span><span lang="FA" style="font-size: 11pt font-family: Lotus">سرم،
</span><span dir="ltr">ox-LDL</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>، </span><span dir="ltr">MDA</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span> و </span><span dir="ltr">TAC</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span> بیماران
اندازهگیری شد</span><span dir="ltr"></span><span dir="ltr"></span><span dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span><span dir="rtl"></span><span dir="rtl"></span><span style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span> <u><span lang="FA">یافتهها</span></u><span lang="FA">: رژیم مداخله
با کاهش </span></span><span dir="ltr">ox-LDL</span><span dir="rtl"></span><span dir="rtl"></span><span style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span> <span lang="FA">(5/0±1/3- در برابر 4/0±7/0- ، 003/0</span></span><span dir="ltr">P=</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>)،
</span><span dir="ltr">MDA</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>
(2/0±1/1- در برابر 1/0±3/0- 0، 006/0</span><span dir="ltr">P=</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>) و قند خون ناشتا (7/6±7/28- در
برابر 5/5±5/19- ، 001/0</span><span dir="ltr"></span><span dir="ltr"></span><span dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> P <</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span>)
همراه بود، اما تفاوت معنیداری در تغییرات </span><span dir="ltr">TAC</span><span dir="rtl"></span><span dir="rtl"></span><span style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span> <span lang="FA">بین دو گروه
مشاهده نگردید. <u>نتیجهگیری</u>: رژیم غذایی </span></span><span dir="ltr">TLC</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-size: 11pt font-family: Lotus"><span dir="rtl"></span><span dir="rtl"></span> بر مبنای
دریافت حبوبات غیر سویا شاخصهای استرس اکسیداتیو و قند خون را در بیماران دیابتی
بهبود میبخشد. <o:p /></span></p>
<p class="Abstract" style="direction: ltr unicode-bidi: embed"><u>Introduction</u>: Oxidative stress plays a
key role in the pathogenesis of late diabetic complications, the markers of
which could be improved by the beneficial effects of legumes. <u>Materials and
Methods</u>: In this randomized crossover trial, 24 overweight subjects, aged
50-80 years, with type 2 diabetes, were selected. We aimed to determine the
effects of non-soybean legumes consumption on oxidative stress markers such as
ox-LDL (oxidative LDL), MDA (Malonedialdehyde) and TAC (total antioxidant
capacity) in type 2 diabetic patients. The subjects were randomly assigned into
two groups, receiving two diets – the TLC (controls) or the TLC diet with
legumes (receiving 2 servings of legumes instead of meat three days of the week
in the TLC diet). Duration of each diet was 8 weeks with a 4 week wash-out
period. At the beginning and end of each dietary period, fasting plasma
glucose, ox-LDL, MDA, TAC and weight were measured. <u>Results</u>: After the
nutritional intervention, diabetic patients, those individuals who followed the
legume-based TLC diet had significant reduction in ox- LDL (-3.1±0.5 vs.
-0.7±0.4 P=0.003) and MDA (-1.1±0.2 vs. -0.3±0.1 P=0.006), but no change was observed in the TAC and BMI
of the case and control groups. <u>Conclusions</u>: The legume-based TLC diet
improves oxidative stress markers in diabetic patients, compared to the
legume-free TLC diet. </p>
دیابت نوع 2, حبوبات, LDL اکسید شده, مالون دی آلدئید, ظرفیت تام آنتیاکسیدانی
Type 2 diabetes, Legumes, oxidative LDL, Malonedialdehyde, Total antioxidant capacity
319
328
http://ijem.sbmu.ac.ir/browse.php?a_code=A-10-595-19&slc_lang=fa&sid=1
ensieh
fallah noroozinejad
انسیه
فلاح نوروزی نژاد
fattanehfallah@yahoo.com
4000319475328460025064
4000319475328460025064
No
shahid beheshti medical university of medical scienc
مرکز تحقیقات و غدد درونریز، پژوهشکده علوم غدد درونریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی
somaye
hosseinpour niazi
سمیه
حسین پور نیازی
s.hossainpour@yahoo.com
4000319475328460025065
4000319475328460025065
No
shahid beheshti medical university of medical scienc
مرکز تحقیقات و غدد درونریز، پژوهشکده علوم غدد درونریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی
Parvin
Mirmiran
پروین
میرمیران
mirmiran@endocrine.ac.ir
4000319475328460025066
4000319475328460025066
Yes
shahid beheshti medical university of medical science
دانشگاه علوم پزشکی شهید بهشتی
mehdi
hedayati
مهدی
هدایتی
4000319475328460025067
4000319475328460025067
No
shahid beheshti medical university of medical scienc
مرکز تحقیقات و غدد درونریز، پژوهشکده علوم غدد درونریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی
hossein
delshad
حسین
دلشاد
4000319475328460025068
4000319475328460025068
No
shahid beheshti medical university of medical scienc
مرکز تحقیقات و غدد درونریز، پژوهشکده علوم غدد درونریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی
delshad1336@yahoo.com
4000319475328460025069
4000319475328460025069
No