Effect of Legumes Intake on the Oxidative Stress Markers in Type 2 Diabetes Patients: A Randomized Cross-over Study
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Ensieh Fallah noroozinejad , Somaye Hosseinpour niazi , Parvin Mirmiran , Mehdi Hedayati , Hossein Delshad  |
shahid beheshti medical university of medical science , mirmiran@endocrine.ac.ir |
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Abstract: (9134 Views) |
Introduction: Oxidative stress plays a
key role in the pathogenesis of late diabetic complications, the markers of
which could be improved by the beneficial effects of legumes. Materials and
Methods: In this randomized crossover trial, 24 overweight subjects, aged
50-80 years, with type 2 diabetes, were selected. We aimed to determine the
effects of non-soybean legumes consumption on oxidative stress markers such as
ox-LDL (oxidative LDL), MDA (Malonedialdehyde) and TAC (total antioxidant
capacity) in type 2 diabetic patients. The subjects were randomly assigned into
two groups, receiving two diets – the TLC (controls) or the TLC diet with
legumes (receiving 2 servings of legumes instead of meat three days of the week
in the TLC diet). Duration of each diet was 8 weeks with a 4 week wash-out
period. At the beginning and end of each dietary period, fasting plasma
glucose, ox-LDL, MDA, TAC and weight were measured. Results: After the
nutritional intervention, diabetic patients, those individuals who followed the
legume-based TLC diet had significant reduction in ox- LDL (-3.1±0.5 vs.
-0.7±0.4 P=0.003) and MDA (-1.1±0.2 vs. -0.3±0.1 P=0.006), but no change was observed in the TAC and BMI
of the case and control groups. Conclusions: The legume-based TLC diet
improves oxidative stress markers in diabetic patients, compared to the
legume-free TLC diet. |
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Keywords: Type 2 diabetes, Legumes, oxidative LDL, Malonedialdehyde, Total antioxidant capacity |
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Full-Text [PDF 342 kb]
(2501 Downloads)
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Type of Study: Original |
Subject:
Nutrition Received: 2014/07/22 | Accepted: 2014/11/19 | Published: 2015/01/11
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