|
Study of the Effect of Silymarin on Cardiac Hypertrophy in Young and D-galactose-Aged Rats
|
F Salem    , A Komaki , E Shiri , Kh Ramezani-Aliakbari , Sh Nosrati , SE Hosseini , F Ramezani-Aliakbari |
| Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran, , f.ramezani@umsha.ac.ir |
|
|
Abstract: (12 Views) |
Introduction: Aging is associated with cardiac hypertrophy and heart failure. Silymarin has indicated protective effects in improving cardiovascular diseases. This study aimed to investigate the effect of Silymarin on cardiac hypertrophy in D-galactose- induced aged rats. Materials and Methods: Rats were randomly divided into 5 groups (5 rats per group): control, Silymarin, D-galactose-induced aged group, aged group receiving normal saline, and aged group treated with Silymarin.Aged animals received D-galactose at a dose of 150 mg/ kg/day through intraperitoneal injection for 8 weeks. The aged group treated with Silymarin were co-treated with Silymarin at a dose of 50 mg/ kg/day through gavage for 8 weeks. We performed a histological assay of heart tissue. Malondialdehyde and Superoxide dismutase levels were measured in heart tissue. Results: Findings showed that D-galactose-induced aging caused increased cardiac hypertrophy and malondialdehyde levels and reduced Superoxide dismutase in heart tissue. However, Silymarin treatment decreased cardiac hypertrophy in aging rats. Also, the young rats receiving Silymarin showed cardiac hypertrophy and a significant increase in malondialdehyde levels in heart tissue compared to the control group. Conclusion: The findings of the present study showed that Silymarin could ameliorate cardiac hypertrophy resulting from D-galactose-induced aging. However, Silymarin also induced cardiac hypertrophy and oxidative stress in young rats. |
|
| Keywords: D-galactose, Silymarin, Aging, Rat, Cardiac Hypertrophy |
|
|
Full-Text [PDF 1054 kb]
(13 Downloads)
|
Type of Study: Original |
Subject:
Cardiology
Received: 2026/05/2 | Accepted: 2026/07/11 | Published: 2026/04/30
|
|
|
|
|
|
|
| Add your comments about this article |
|
|
|
