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:: Volume 17, Issue 3 (9-2015) ::
2015, 17(3): 238-250 Back to browse issues page
The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats
Saeed Changizi Ashtiyani Dr , Parvin Yarmohammady , Nasser Hosseini , Iraj Salehi Dr, Majid Ramazani Dr
Associate Prof Department of physiology, Arak University of medical sciences. Arak/ Iran , dr.ashtiyani@arakmu.ac.ir
Abstract:   (4258 Views)

Introduction: Althaea officinalis is listed among potential anti-diabetic herbal medicines. This study aimed to investigate the effect of the alcoholic extract of Althaea officinalis root on lowering blood sugar and lipid profiles in the treatment of type I diabetes. Materials and Methods: Seventy male Wistar rats were divided into 7 groups (n=10 each) as follows: Non-diabetic control, sham receiving normal saline (NS), and the diabetic control groups, which received extract of Althaea officinalis at doses of 200, 400, 800 mg/kg body weight respectively through gastric gavage and glibenclamide 5 mg/kg, for a period of 4 weeks. Diabetes was induced by streptozotocin (STZ) (60 mg/kg body weight). Results: The hydroalcoholic extract of Althaea officinalis significantly decreased blood glucose levels (P<0.05) in diabetic rats treated, at all doses (200, 400, 800 mg/kg). Significant improvement was also observed in dyslipidemia (p<0.05), caused by diabetes mellitus, as confirmed by reduced levels of total cholesterol, triglycerides, LDL and significantly elevated levels of HDL. Fasting blood glucose levels of glibenclamide treated rats 200 mg/kg doses of the extract were significantly lower than those in the diabetic control group (P<0.05). However levels of fasting blood glucose in the group treated with 400, 800 mg/kg doses of the extract had no significant difference, as compared to the group treated with glibenclamide (P<0.05). Conclusion: Results of this study discovered significant hypolipidemic and hypoglycemic effects for the extract of Althaea officinalis in Wistar rats.

Keywords: Althea officinalis, Diabetes, Dyslipidemia, Streptozotocin
Full-Text [PDF 442 kb]   (908 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2015/03/26 | Accepted: 2015/07/5 | Published: 2015/09/16
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Changizi Ashtiyani S, Yarmohammady P, Hosseini N, salehi I, Ramazani M. The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats . Iranian Journal of Endocrinology and Metabolism. 2015; 17 (3) :238-250
URL: http://ijem.sbmu.ac.ir/article-1-1918-en.html

Volume 17, Issue 3 (9-2015) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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