The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats
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Saeed Changizi Ashtiyani , Parvin Yarmohammady , Nasser Hosseini , Iraj Salehi , Majid Ramazani  |
Department of physiology, Arak University of medical sciences. Arak/ Iran , dr.ashtiyani@arakmu.ac.ir |
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Abstract: (9769 Views) |
Introduction: Althaea officinalis
is listed among potential anti-diabetic herbal medicines. This study aimed to
investigate the effect of the alcoholic extract of Althaea officinalis root
on lowering blood sugar and lipid profiles in the treatment of type I diabetes.
Materials and Methods: Seventy male Wistar rats were divided into 7
groups (n=10 each) as follows: Non-diabetic control, sham receiving normal
saline (NS), and the diabetic control groups, which received extract of Althaea
officinalis at doses of 200, 400, 800 mg/kg body weight respectively
through gastric gavage and glibenclamide 5 mg/kg, for a period of 4 weeks.
Diabetes was induced by streptozotocin (STZ) (60 mg/kg body weight). Results:
The hydroalcoholic extract of Althaea officinalis significantly
decreased blood glucose levels (P<0.05) in diabetic rats treated, at all
doses (200, 400, 800 mg/kg). Significant improvement was also observed in
dyslipidemia (p<0.05), caused by diabetes mellitus, as confirmed by reduced
levels of total cholesterol, triglycerides, LDL and significantly elevated
levels of HDL. Fasting blood glucose levels of glibenclamide treated rats 200
mg/kg doses of the extract were significantly lower than those in the diabetic
control group (P<0.05). However levels of fasting blood glucose in the group
treated with 400, 800 mg/kg doses of the extract had no significant difference,
as compared to the group treated with glibenclamide (P<0.05). Conclusion:
Results of this study discovered significant hypolipidemic and hypoglycemic
effects for the extract of Althaea officinalis in Wistar rats. |
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Keywords: Althea officinalis, Diabetes, Dyslipidemia, Streptozotocin |
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Full-Text [PDF 442 kb]
(2449 Downloads)
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Type of Study: Original |
Subject:
Endocrinology Received: 2015/03/26 | Accepted: 2015/07/5 | Published: 2015/09/16
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