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Investigation on the Levels of IGF-I Receptor and IGF-I Binding Protein I in the Brain of Insulin Resistant Rats
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A. Parvaneh Tafreshi   , R Jalal , S Darvishalipour , H Sepehri , K Adeli |
| , tafreshi@nigeb.ac.ir |
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Abstract: (11867 Views) |
| Abstract
Introduction: There is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor (IGF-I) to transduce the signals in different areas of the brain. In this article we aimed at investigating whether the expression of IGF-I receptor and IGF-I binding proteins (IGFBP1) is changed in the brain of the diabetic animal model. Materials and Methods: To induce insulin resistance, adult wistar rats were fed with fructose in their drinking water (10%). The expression of IGF-I receptor and its binding protein were examined immunohistochemically. Results: Our findings demonstrated that the expression of IGF-I receptor and IGF-I binding protein were not changed in different areas of the brain in insulin resistant rats, compared to those in the control rats. Conclusion: The unchanged expression levels of IGF-I receptor and its binding protein I not imply the lack of involvement of the IGF-I signal transduction pathway in the insulin resistant brain, further investigations are to clarify the issue. |
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| Keywords: Diabetes type II, Insulin Resistance, Brain, IGF binding protein I, IGF-I receptor |
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Full-Text [PDF 381 kb]
(2458 Downloads)
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Type of Study: Original |
Received: 2010/04/8 | Published: 2009/04/15
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