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:: Volume 11, Issue 6 (4-2009) ::
2009, 11(6): 707-712 Back to browse issues page
Investigation on the Levels of IGF-I Receptor and IGF-I Binding Protein I in the Brain of Insulin Resistant Rats
A. Parvaneh Tafreshi Dr. , R Jalal Dr., S Darvishalipour , H Sepehri Dr., K Adeli Dr.
, tafreshi@nigeb.ac.ir
Abstract:   (8164 Views)
Abstract Introduction: There is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor (IGF-I) to transduce the signals in different areas of the brain. In this article we aimed at investigating whether the expression of IGF-I receptor and IGF-I binding proteins (IGFBP1) is changed in the brain of the diabetic animal model. Materials and Methods: To induce insulin resistance, adult wistar rats were fed with fructose in their drinking water (10%). The expression of IGF-I receptor and its binding protein were examined immunohistochemically. Results: Our findings demonstrated that the expression of IGF-I receptor and IGF-I binding protein were not changed in different areas of the brain in insulin resistant rats, compared to those in the control rats. Conclusion: The unchanged expression levels of IGF-I receptor and its binding protein I not imply the lack of involvement of the IGF-I signal transduction pathway in the insulin resistant brain, further investigations are to clarify the issue.
Keywords: Diabetes type II, Insulin Resistance, Brain, IGF binding protein I, IGF-I receptor
Full-Text [PDF 381 kb]   (1400 Downloads)    
Type of Study: Original |
Received: 2010/04/8
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Parvaneh Tafreshi A, Jalal R, Darvishalipour S, Sepehri H, Adeli K. Investigation on the Levels of IGF-I Receptor and IGF-I Binding Protein I in the Brain of Insulin Resistant Rats. Iranian Journal of Endocrinology and Metabolism. 2009; 11 (6) :707-712
URL: http://ijem.sbmu.ac.ir/article-1-929-en.html


Volume 11, Issue 6 (4-2009) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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