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Investigation on the Levels of IGF-I Receptor and IGF-I Binding Protein I in the Brain of Insulin Resistant Rats
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آزیتا پروانه تفرشی   ، راضیه جلال ، شمیلا درویش علی پور ، حوری سپهری ، خسرو عادلی |
| ، tafreshi@nigeb.ac.ir |
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چکیده: (10914 مشاهده) |
| Abstract
Introduction: There is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor (IGF-I) to transduce the signals in different areas of the brain. In this article we aimed at investigating whether the expression of IGF-I receptor and IGF-I binding proteins (IGFBP1) is changed in the brain of the diabetic animal model. Materials and Methods: To induce insulin resistance, adult wistar rats were fed with fructose in their drinking water (10%). The expression of IGF-I receptor and its binding protein were examined immunohistochemically. Results: Our findings demonstrated that the expression of IGF-I receptor and IGF-I binding protein were not changed in different areas of the brain in insulin resistant rats, compared to those in the control rats. Conclusion: The unchanged expression levels of IGF-I receptor and its binding protein I not imply the lack of involvement of the IGF-I signal transduction pathway in the insulin resistant brain, further investigations are to clarify the issue. |
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متن کامل [PDF 381 kb]
(2190 دریافت)
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نوع مطالعه: پژوهشی |
دریافت: 1389/1/19 | انتشار: 1388/1/26
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