Introduction: Adequate nutrition is crucial for growth and maintenance of the body skeleton health. Nutrients consumed affect leptin and adiponectin levels and bone mass. This study was done to determe the relationship between serum leptin, adiponectin and bone mass with energy intake and nutrients in postmenopausal women, 40-60 years old. Material and Methods: The present cross-sectional study was done on 85 postmenopausal women, aged 40-60 years. Samples of fasting blood were taken to determine concentrations of leptin and adiponectin of serum and bone mineral density was measured by the DXA method in the two areas of L2-4 and the femoral neck. Food intake was documented using questionnaires including frequency of food and was analyzed by FP2 Software. Results: Leptin had a negative relationship with energy intake, protein and magnesium and a positive relationship with carbohydrate there was a positive relationship between adiponectin and energy and carbohydrate. BMD of femur had a negative relationship with energy and carbohydrate, while it had positive relationship with calcium, and there was direct and significant relationship between BMD of the spine and zinc. Conclusion: Increase in consumption of carbohydrate and decrease in consumption of protein lead to increase in leptin. Consumption of calcium and zinc can have a protective effect on bones.