|
Association between Plant-Based Diet Index Adherence and the Risk of Cardiovascular Disease among Adults with Multimorbidity: A Cohort from Tehran Lipid and Glucose Study
|
M Golzarand    , A Salari-Moghaddam , P Mirmiran , F Azizi |
| Nutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, , mahdieh_golzarand@yahoo.com |
|
|
Abstract: (9 Views) |
Introduction: In recent years, many cohort studies have investigated the association between plant-based diets and cardiovascular disease (CVD) risk. However, very few studies have examined the association between adherence to plant-based diet indices and CVD risk in individuals with multiple comorbidities. Therefore, the present study was designed to investigate this association. Materials and Methods: In this cohort study, 1688 adults were selected from the Tehran Lipid and Sugar Study. Participants' dietary intake and adherence to the plant-based diet index (PDI) were assessed using a food frequency questionnaire. The association between PDIs and CVD incidence was examined using Cox proportional hazards regression. Results: Participants' mean age was 43.4 years, and 53.7% were women. During the 10-year follow-up, 166 cases of cardiovascular disease were identified. After adjustment for all potential confounders, the hazard ratio (95% confidence interval) for CVD per standard deviation (SD) increase in the overall PDI was 0.94 (0.80-1.11), the healthful PDI (hPDI) was 0.85 (0.71-1.02), and the unhealthful PDI (uPDI) was 1.24 (1.04-1.46). Based on the restricted cubic spline, the observed association between uPDI and CVD was nonlinear. Conclusion: Higher adherence to uPDI appears to be associated with an increased risk of CVD in individuals with multiple comorbidities. Further well-designed cohort studies across different populations are recommended to inform this decision. |
|
| Keywords: Plant-based diet index, Multimorbidity, Cardiovascular disease, Diet |
|
|
Full-Text [PDF 932 kb]
(17 Downloads)
|
Type of Study: Original |
Subject:
Nutrition
Received: 2026/02/25 | Accepted: 2026/07/11 | Published: 2026/04/30
|
|
|
|
|
|
|
| Add your comments about this article |
|
|
|
