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Association of Lifelines Diet Score (LLDS) with Risk of Pancreatic Steatosis: A Case-Control Study
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N Naderi    , M Momenan , A Hekmatdoost , M Chegini , M Bahrizadeh , A Sadeghi , Z Yari |
| Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran , zahrayari_nut@yahoo.com |
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Abstract: (11 Views) |
Introduction: Pancreatic steatosis is associated with a spectrum of metabolic outcomes. Given the absence of specific treatments, diet quality-being modifiable-may play a preventive role. This study aimed to examine the association between the Lifelines Diet Score (LLDS) and the risk of pancreatic steatosis. Materials and Methods: In this case-control study, 278 patients with gallstones were evaluated, including 89 cases with pancreatic steatosis (diagnosed via ultrasound) and 189 controls without steatosis. Dietary quality was assessed using a validated food frequency questionnaire and the LLDS. Participants were categorized into low, middle, and high LLDS tertiles. Multivariable logistic regression was used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI). Results: The mean LLDS was significantly higher in the control group than in the case group (36.07 vs. 32.76; P<0.001). In the fully adjusted model, participants in the highest LLDS tertile had a 33% reduced risk of pancreatic steatosis (aOR=0.67; 95% CI: 0.32–0.98), with a significant trend across tertiles (P for trend=0.048). Conclusion: Adherence to a high-quality diet, as reflected by the LLDS, is independently associated with a lower risk of pancreatic steatosis. These findings underscore the importance of guideline-based nutritional strategies in the prevention and management of fatty pancreas disease and highlight the need for prospective studies and dietary intervention trials to establish causal links.
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| Keywords: Pancreatic steatosis, Lifelines Diet Score, Diet quality |
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Full-Text [PDF 956 kb]
(9 Downloads)
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Type of Study: Original |
Subject:
Nutrition
Received: 2025/08/20 | Accepted: 2025/10/11 | Published: 2025/03/30
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