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:: Volume 21, Issue 3 (11-2019) ::
2019, 21(3): 123-137 Back to browse issues page
The Association of Omentin Gene Expression in Visceral and Subcutaneous Adipose Tissues with Plasma Fatty Acids Profile and Dietary Fatty Acids
Mohammad Nosrati-oskouie , Mohammad Safarian , Emad Yuzbashian , Golaleh Asghari Dr , Maryam Zarkesh Dr , Nazanin sadat Aghili-Moghaddam , Mahdi Hedayati Dr , Parvin Mirmiran Dr , Alireza Khalaj
, Research Institute for Endocrine Sciences , mirmiran@endocrine.ac.ir
Abstract:   (336 Views)

Introduction: Omentin, an adipokine, with anti-inflammatory effects reduces insulin resistance, and can hence, play an important role in prevention of cardiovascular disease and diabetes. The present study aimed to investigate the association of plasma and dietary fatty acids with gene expression of omentin in visceral and subcutaneous adipose tissues. Materials and Methods: Visceral and subcutaneous adipose tissues and fasting blood samples were obtained from 50 obese and 47 non-obese participants, who had undergone elective abdominal surgery. Dietary intakes were assessed using a food frequency questionnaire. Relative gene expression of omentin in visceral and subcutaneous adipose tissues was measured by Real-Time PCR and plasma fatty acids were measured using gas chromatography. Results: Omentin gene expression in visceral adipose tissue was higher in non-obese participants, compared to obese ones; however, no difference was found in subcutaneous adipose tissue. A significant direct association was observed between omentin gene expression in visceral adipose tissue with dietary monounsaturated fatty acid (MUFA) (P=0.011, β=0.394) in obese subjects and the plasma omega 6: omega 3 ratio (P=0.029, β=0.385) in non-obese subjects after adjustment for confounders. No association was observed between omentin gene expression in subcutaneous adipose tissue and plasma and dietary fatty acids. Conclusion: Dietary intakes of MUFA in obese participants and plasma omega 6: omega 3 ratio in non-obese ones were directly associated with omentin gene expression in visceral adipose tissue. Therefore, higher omentin gene expression by increasing dietary MUFA may be related to improvement of obesity and its associated comorbidities.

Keywords: Omentin, Saturated fatty acids, Monounsaturated fatty acids, polyunsaturated fatty acids, Omega-6: Omega-3 ratio, Visceral adipose tissue, Subcutaneous adipose tissue
Full-Text [PDF 1827 kb]   (149 Downloads)    
Type of Study: Original | Subject: Genetic
Received: 2019/08/6 | Accepted: 2019/09/29
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nosrati-oskouie M, safarian M, Yuzbashian E, Asghari G, zarkesh M, Aghili-Moghaddam N S, et al . The Association of Omentin Gene Expression in Visceral and Subcutaneous Adipose Tissues with Plasma Fatty Acids Profile and Dietary Fatty Acids. Iranian Journal of Endocrinology and Metabolism. 2019; 21 (3) :123-137
URL: http://ijem.sbmu.ac.ir/article-1-2615-en.html


Volume 21, Issue 3 (11-2019) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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