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:: Volume 21, Issue 3 (11-2019) ::
2019, 21(3): 163-173 Back to browse issues page
The Effect of Aerobic Exercise on Serum Orexin-A, Subcutaneous Adipose Tissue Thermogenic Gene Expression Indices and Insulin Resistance in High-fat Diet-induced Obese Rats
Ebrahim Moslehi , Vazgen Minasian Dr , Heibatollah Sadeghi Dr
University of Isfahan , v.minasian@spr.ui.ac.ir
Abstract:   (809 Views)
Introduction: Compared to other adipose tissues, Subcutaneous Adipose Tissue (SAT), may have different effects on health and insulin resistance. The purpose of this study was to investigate the effect of aerobic exercise on serum orexin-A (OXA), SAT thermogenic indices gene expression, and insulin resistance in high-fat diet-induced obese rats. Materials and Methods: Thirty-two male wistar rats with an average weight of 180-200 g were randomly assigned into 4 equal groups: normal fat diet (NFD), high-fat diet-induced obesity (HFDO), normal fat diet after high-fat diet-induced obesity (HFDO-NFD) and the aerobic exercise group with normal fat diet after high-fat diet-induced obesity (HFDO-AEX). After induction of obesity in the HFDO group and 48 hours after eight weeks of aerobic exercise in other groups (60% of maximum exercise capacity), fasting levels of serum OXA, FBS, insulin resistance, lipid profiles, and gene expression of PGC-1α and UCP1 in SAT were measured. Results: Results showed that, following HFD, compared to the NFD group, levels of OXA, HDL-C, PGC-1α and UCP1 gene expression in the HFDO group, significantly decreased, and lipid profiles, Lee index, FBS, insulin and insulin resistance significantly increased (P<0.01). Also after aerobic exercise in the HFDO-AEX group, compared to the HFDO group, levels of OXA (34.74%), HDL-C (23.65%), PGC-1α and UCP1 genes expression (77.38% and 78.72%, respectively) increased and values of lipid profile, Lee index (18.34%), FBS (32.28%), insulin (4.01%) and insulin resistance (37.48%) were significantly decreased (P≤0.001), changes however, not significant in the HFDO-NFD group. Conclusion: Data obtained suggest that aerobic exercise by an increase in the OXA and alteration in the SAT thermogenic gene expression indices may improve insulin resistance and blood lipid profiles.

Keywords: Obesity, Aerobic exercise, Orexin-A, PGC-1α, UCP1
Full-Text [PDF 1977 kb]   (231 Downloads)    
Type of Study: Original | Subject: Exercise
Received: 2019/05/12 | Accepted: 2019/10/7
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Moslehi E, Minasian V, Sadeghi H. The Effect of Aerobic Exercise on Serum Orexin-A, Subcutaneous Adipose Tissue Thermogenic Gene Expression Indices and Insulin Resistance in High-fat Diet-induced Obese Rats. Iranian Journal of Endocrinology and Metabolism. 2019; 21 (3) :163-173
URL: http://ijem.sbmu.ac.ir/article-1-2572-en.html


Volume 21, Issue 3 (11-2019) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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