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Study Effects of Resveratrol, Cuminumcyminum, Essence and Vitamin C on Blood Sugar, Lipid, Insulin Resistance and Advanced Glycatedend Product (AGEs) in Type2 Diabetic Patients
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Maryam Foroghi    , Keihan Ghatre samani , Esfandiar Heidarian , Morteza Nikokar , Samaneh Fazeli |
| Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord ,IR Iran. , kgsamani@yahoo.com |
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Abstract: (6145 Views) |
Introduction: Advanced glycated end products (AGEs) play an important role in the progression of diabetes and exacerbation of its complications. The aim of this study was to investigate the effects of supplementation of Resveratrol, the essential oil of cumin and Vitamin C, on levels of blood sugar, lipid, insulin resistance and AGEs in type 2 diabetic patients. Materials and Methods: In this double-blind randomized clinical trial, diabetic patients were randomly divided into four groups: Cumin essential oil, Resveratrol supplement, vitamin C and the control group. After two months, Insulin resistance, AGEs, Insulin, glucose and lipids were measured, using standard kits and results were analyzed. Results: There were no significant differences between the groups in the beginning of the study. Insulin resistance and AGEs showed no significant differences between the four groups after study, although in the Resveratrol group, levels of body mass index (BMI) and glycosylated hemoglobin (HbA1C) were reduced (p=0.001, p=0.04). In the cumin group, BMI (p=0.001), triglyceride (p=0.01) and HbA1C (p=0.01) levels decreased significantly after intervention. In the vitamin C and control groups, none of the measured variables were significantly different post-intervention. Conclusion: Resveratrol can be effective in weight loss and metabolic control in diabetic patients. Cumin showed high efficacy in the improvement of sugar and dyslipidemia indices in these patients.
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| Keywords: Type 2 diabetes, Cumin, Vitamin C, Resveratrol, Advanced Glycated end product (AGEs) |
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Full-Text [PDF 343 kb]
(1531 Downloads)
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Type of Study: Original |
Subject:
General
Received: 2018/02/4 | Accepted: 2018/10/8 | Published: 2018/12/15
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foroghi M, Ghatre samani K, Heidarian E, Nikokar M, fazeli S. Study Effects of Resveratrol, Cuminumcyminum, Essence and Vitamin C on Blood Sugar, Lipid, Insulin Resistance and Advanced Glycatedend Product (AGEs) in Type2 Diabetic Patients. Iranian Journal of Endocrinology and Metabolism 2018; 20 (4) :169-176 URL: http://ijem.sbmu.ac.ir/article-1-2382-en.html
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