Introduction: Metabolic syndrome (MetS) is a cluster of interrelated risk factors for cardiovascular disease (CVD) and diabetes. The aim of this study was to investigate the effect of the healthy diet with sesame seed consumption on anthropometric indices, lipid profile and atherogenic index of plasma (AIP) in overweight and obese women with MetS. Materials and Methods: In this clinical trial, 51 overweight and obese women with MetS were given recom­mendations for a healthy diet with (n=22) and without (n=24) supplementation 50 g/day of sesame seed powder for 6 weeks. Weight, Body Mass Index (BMI), waist circumference, waist circumference to height ratio, percentage of body fat mass, LAP (Lipid Accumulation Product) and serum levels of triglycerides (TG), total cholesterol (TC), LDL-C, HDL-C, LDL-C/HDL-C ratio, TC/HDL-C ratio and AIP were determined at baseline and at the end of the study. Results: Reductions in weight, waist circumference, and BMI were not significant at end of study. Also, no significant differences were observed in other anthropometric indices. The reductions in lipid profile and AIP were not significant. Findings, HDL-C showed no significant increase. Conclusion: Daily consumption of 50 g sesame seed for 6 weeks had no effect on the anthropometric parameters, lipid profile or AIP in women with metabolic syndrome. However, more investigations are necessary to confirm these findings.