[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
:: Volume 16, Number 5 (1-2015) ::
2015, 16(5): 329-337 Back to browse issues page
Effects of Alcoholic and Aqueous Extract of Barberry, Jujube and Saffron Petals on Serum Level of Adiponectin and Lipid Profile in Diabetic Rats
Dr Mina Hemmati *, Somaye Asghari, Elham Zohoori
Assistant professor in clinical biochemistry Birjand University of Medical sciences , minahemmati@bums.ac.ir
Abstract:   (4363 Views)

Introduction: Adiponectin is a protein hormone secreted from adipose tissue that can affect diabetes progression. The aim of this study was to investigate the changes in serum levels of adiponectin in diabetic rats treated with alcoholic and aqueous extracts of three medicinal plants, jujube (Ziziphus jujuba), barberry (Berberis vulgaris) and saffron (Crocus sativus). Materials and Methods: In this study, streptozocin-induced diabetic rats were treated with two doses of aqueous and alcoholic extracts of the herbs, 25 and 100 mg/kg respectively, for 21 days. After the treatment period, the levels of adiponectin, fasting blood glucose, triglycerides and cholesterol were measured and the results were analyzed using one way ANOVA test. Results: In all the diabetic groups receiving extracts, serum levels of fasting blood glucose, triglycerides and VLDL (very low density lipoprotein), showed a significant decrease (P<0.05). Serum level of HDL (high density lipoprotein) increased significantly only in the group receiving jujube (P<0.05), whereas adiponectin level was significantly increased in all the treated groups. Conclusion: Given the role of adiponectin in regulating lipid metabolism, and the increased level of adiponectin in the treated diabetic groups, it can be said that the extracts regulate glucose and lipid metabolism by changes in adiponectin level. Further studies are recommended to confirm these findings.

Keywords: Diabetes, Adiponectin, Lipid profile, Berberis vulgaris, Crocus sativus, Ziziphus jujubamill
Full-Text [PDF 500 kb]   (1076 Downloads)    
Type of Study: Original | Subject: Biochemistry
Received: 2014/07/6 | Accepted: 2014/11/18 | Published: 2015/01/11
Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hemmati M, Asghari S, Zohoori E. Effects of Alcoholic and Aqueous Extract of Barberry, Jujube and Saffron Petals on Serum Level of Adiponectin and Lipid Profile in Diabetic Rats. Iranian Journal of Endocrinology and Metabolism. 2015; 16 (5) :329-337
URL: http://ijem.sbmu.ac.ir/article-1-1756-en.html
Volume 16, Number 5 (1-2015) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.05 seconds with 803 queries by yektaweb 3506