Interaction of APOC3 Polymorphism and Dietary Fats on the Risk of Metabolic Syndrome
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Firoozeh Hosseini-Esfahani , Maryam S Daneshpour , Parvin Mirmiran , Yadollah Mehrabi , Mehdi Hedayati , Fereidoun Azizi  |
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , azizi@endocrine.ac.ir |
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Abstract: (8529 Views) |
Introduction: The aim of this study
was to evaluate the interaction between dietary fatty acids and the genetic
variant of APOC3 rs5128 3238C>G in relation to metabolic syndrome (MetS)
components in adults. Materials and Methods: In this matched nested
case-control study, 755 MetS subjects and 755 controls were selected from among
participants of the Tehran Lipid and Glucose Study. Dietary intake was
determined using a valid and reliable food frequency questionnaire. APOC3 was
genotyped by the conventional polymerase chain reaction and restriction
fragment length polymorphism. Results: Mean ages of men and women were
not different in cases and controls. The frequency of C allele was 81%, which did
not differ in cases and controls or in men and women. Compared to CC genotype,
low HDL-C risk was increased in women with the CG+GG genotypes and with
cholesterol intakes ≥208 mg/day (OR: 1.93). In men with the CG+GG genotypes and
saturated fatty acid (SFA) intakes ≥9.8% of energy, OR of high diastolic blood
pressure (BP) was 2.15(1-1.46), compared to individuals with SFA intake
<9.8% of energy and CC genotype. Compared to the CC genotype, the risk of
high diastolic BP was higher in men carrying the G allele and consuming
mono-unsaturated fatty acid (MUFA) intakes ≥9.4% of energy. Conclusions:
Results demonstrate a nutri-genetic interaction between rs5128 and fat intakes
in relation to components of MetS individuals with G allele carriers and
higher intakes of cholesterol, MUFA or SFA had higher risk of low HDL-C and
hypertension than the CC genotype. |
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Keywords: Metabolic Syndrome, Polymorphism, Fatty acid intakes |
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Full-Text [PDF 373 kb]
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Type of Study: Original |
Subject:
Nutrition Received: 2014/07/6 | Accepted: 2014/10/19 | Published: 2015/01/11
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Hosseini-Esfahani F, Daneshpour M S, Mirmiran P, Mehrabi Y, Hedayati M, Azizi F. Interaction of APOC3 Polymorphism and Dietary Fats on the Risk of Metabolic Syndrome. Iranian Journal of Endocrinology and Metabolism 2015; 16 (5) :345-355 URL: http://ijem.sbmu.ac.ir/article-1-1755-en.html
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