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:: Volume 14, Issue 3 (9-2012) ::
2012, 14(3): 207-214 Back to browse issues page
Effect of Vitamin C Supplementation on Fasting and Postprandial Oxidative Stress, Inflammatory Markers and Lipid Profiles in Type 2 Diabetic Patients
Zohreh Mazloom Dr, Najmeh Hejazi , Mohammad –Hossein Dabbaghmanesh Dr, Hamid-Reza Tabatabaee
Dept. of Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran. , n20hejazi@yahoo.com
Abstract:   (8551 Views)
Introduction: Diabetes mellitus is one of the most wide spread endocrine disorders and among the most important developing health issues. This disease is associated with increased free radical production and decrease in antioxidant defense systems. In this study we evaluated the effect of vitamin C supplementation on fasting and postprandial oxidative stress, inflammatory markers and lipid profiles in type 2 diabetic patients. Materials and Methods: Thirty patients with type 2 diabetes (age range 25 to 65 years) were randomly divided into two groups, 1) treatment with vitamin C (1000mg/d) and 2) the placebo group. They were supplemented for 6 weeks, after which we measured malondialdehyde, IL-6, hs-CRP and lipid profiles in fasting and postprandial state (after a breakfast containing 80g fat, the same as the first day of the study). Data analysis was carried out using Mann Whitney U test, with P<0.05 being significant by SPSS software version 11. Results: Results showed a significant decrease in fasting (p=0.006) and postprandial MDA (p<0.001) in the vitamin C group compared to controls but there were no significant changes in inflammatory markers and lipid profiles in the fasting and postprandial states. Conclusion: This study suggests that short term vitamin C supplementation can decrease fasting and postprandial oxidative stress, and thereby possibly prevent diabetes complications.
Keywords: Type 2 diabetes mellitus, Oxidative stress, Vitamin C, Postprandial state, Malondialdehyde
Full-Text [PDF 294 kb]   (2897 Downloads)    
Type of Study: Original | Subject: Nutrition
Received: 2011/10/2 | Accepted: 2012/04/11
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mazloom Z, hejazi N, Dabbaghmanesh M –, Tabatabaee H. Effect of Vitamin C Supplementation on Fasting and Postprandial Oxidative Stress, Inflammatory Markers and Lipid Profiles in Type 2 Diabetic Patients. Iranian Journal of Endocrinology and Metabolism. 2012; 14 (3) :207-214
URL: http://ijem.sbmu.ac.ir/article-1-1255-en.html


Volume 14, Issue 3 (9-2012) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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