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:: Volume 14, Issue 2 (7-2012) ::
2012, 14(2): 185-192 Back to browse issues page
Influence of Resistance Training on IL-15 mRNA Expression and the Protein Content in Slow and Fast Twitch Muscles of Diabetic Rats
Mahdieh Molanouri Shamsi, Zuhair Mohammad Hassan , Mehdi Mahdavi, Reza Gharakhanlou, Keyhan Azadmanesh, Lala Baghersad, Rozita Edalat
Tarbiat Modares University , Hassan_zm@modares.ac.ir
Abstract:   (15841 Views)

Introduction: Resistance exercise training represents an effective interventional strategy to augment muscle mass, strength, and function in diabetes. It has been demonstrated that IL-15 (Interleukin-15) can act as an anabolic factor for skeletal muscle, influencing protein metabolism. It has also been suggested that IL-15 could regulate peripheral glucose metabolism. Our aim was to investigate whether resistance training has any effect on IL-15 expression and protein of skeletal muscles in rats with diabetes. Materials and Methods: Rats were divided into the control, the training, and the streptozotocin induced diabetic and diabetic training groups. Training groups performed resistance training exercise which consisted of climbing a 1 m ladder with weight added to the tail. IL-15 Gene expression of soleus and Flexor Hallucis Longus muscles was analyzed using real time. Skeletal muscle protein of IL-15 was measured by ELIZA method. Results: The results of this study indicate that resistance training provided an anabolic stimulus sufficient to maintain the Flexor Hallucis Longus muscle mass of the diabetic training group. IL-15 mRNA levels in soleus were increased in the diabetic training group. Protein levels of IL-15 increased in the training and diabetic training groups in both skeletal muscles. Conclusion: Having a high content of mitochondria and relying on an oxidative pathway, soleus muscle was found to be more affected by diabetes. The lack of correlation of IL-15 mRNA and protein levels is partly due to transcriptional and translational blocks, which are present in the IL-15 gene sequence.

Keywords: Atrophy, STZ induced Diabetes, Resistance Training, IL-15, Skeletal Muscle
Full-Text [PDF 314 kb]   (3732 Downloads)    
Type of Study: Original | Subject: Exercise
Received: 2011/09/22 | Accepted: 2012/01/17
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Molanouri Shamsi M, Hassan Z M, Mahdavi M, Gharakhanlou R, Azadmanesh K, Baghersad L et al . Influence of Resistance Training on IL-15 mRNA Expression and the Protein Content in Slow and Fast Twitch Muscles of Diabetic Rats . Iranian Journal of Endocrinology and Metabolism. 2012; 14 (2) :185-192
URL: http://ijem.sbmu.ac.ir/article-1-1248-en.html


Volume 14, Issue 2 (7-2012) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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