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:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 10, Issue 5 (1-2009) ::
2009, 10(5): 527-532 Back to browse issues page
The Effect of Thiazolidenedione on Glucocorticoid Induced Central Obesity in Rats
M Soveid , MR Kalantarhormozi , Z Azizi , Gh Ranjbar Omrani
, msoveid@sums.ac.ir
Abstract:   (33801 Views)


Introduction: Central obesity is a common complication of glucocorticoids which is associated with insulin resistance. In some studies, thiazolidinediones have decreased central obesity in type 2 diabetic patients. The purpose of this study was to investigate the effect of pioglitazone on glucocorticoid induced central obesity in rats. Materials and Methods: Forty Sprague-Daily rats were divided into 2 groups, with 10 male and 10 female rats in each. In group 1, methylprednisolone succinate 5 mg/kg was injected 3 times per week and pioglitazone 30 mg/kg/day was given. In group 2, only methylprednisolone succinate was administered. After 3 weeks, the rats were sacrificed and visceral fat was removed, and the weight of visceral fat, abdomen circumference and total body weight in the 2 groups were compared. Results: The weight of animals was not different significantly however animals given pioglitazone had less visceral fat (7.32±2.60 vs 11.95± 2.76 gr P<0.001) and lower abdominal circumference (11.92±1.20 vs 14.98±1.74 cm P<0.001). Conclusion: Pioglitazone has antagonistic effect on glucocorticoid induced central obesity.

Keywords: Pioglitazone, Glucocorticoid, Central obesity, Thiazolidinedione
Full-Text [PDF 1385 kb]   (5171 Downloads)    
Type of Study: Original |
Received: 2009/02/5 | Published: 2009/01/15
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Soveid M, Kalantarhormozi M, Azizi Z, Ranjbar Omrani G. The Effect of Thiazolidenedione on Glucocorticoid Induced Central Obesity in Rats. Iranian Journal of Endocrinology and Metabolism 2009; 10 (5) :527-532
URL: http://ijem.sbmu.ac.ir/article-1-629-en.html

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Volume 10, Issue 5 (1-2009) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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