[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
:: Volume 10, Issue 5 (1-2009) ::
2009, 10(5): 527-532 Back to browse issues page
The Effect of Thiazolidenedione on Glucocorticoid Induced Central Obesity in Rats
M Soveid Dr. , MR Kalantarhormozi Dr., Z Azizi Dr., Gh Ranjbar Omrani Dr.
, msoveid@sums.ac.ir
Abstract:   (30256 Views)

Abstract:

Introduction: Central obesity is a common complication of glucocorticoids which is associated with insulin resistance. In some studies, thiazolidinediones have decreased central obesity in type 2 diabetic patients. The purpose of this study was to investigate the effect of pioglitazone on glucocorticoid induced central obesity in rats. Materials and Methods: Forty Sprague-Daily rats were divided into 2 groups, with 10 male and 10 female rats in each. In group 1, methylprednisolone succinate 5 mg/kg was injected 3 times per week and pioglitazone 30 mg/kg/day was given. In group 2, only methylprednisolone succinate was administered. After 3 weeks, the rats were sacrificed and visceral fat was removed, and the weight of visceral fat, abdomen circumference and total body weight in the 2 groups were compared. Results: The weight of animals was not different significantly however animals given pioglitazone had less visceral fat (7.32±2.60 vs 11.95± 2.76 gr P<0.001) and lower abdominal circumference (11.92±1.20 vs 14.98±1.74 cm P<0.001). Conclusion: Pioglitazone has antagonistic effect on glucocorticoid induced central obesity.

Keywords: Pioglitazone, Glucocorticoid, Central obesity, Thiazolidinedione
Full-Text [PDF 1385 kb]   (2833 Downloads)    
Type of Study: Original |
Received: 2009/02/5
Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Soveid M, Kalantarhormozi M, Azizi Z, Ranjbar Omrani G. The Effect of Thiazolidenedione on Glucocorticoid Induced Central Obesity in Rats. Iranian Journal of Endocrinology and Metabolism. 2009; 10 (5) :527-532
URL: http://ijem.sbmu.ac.ir/article-1-629-en.html


Volume 10, Issue 5 (1-2009) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.06 seconds with 32 queries by YEKTAWEB 3858