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Review of Effects of Time-restricted Intermittent Fasting on Body Composition in Overweight and Obese Subjects: Benefits and Potential Adverse Outcomes
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P Mirmiran    , Z Bahadoran |
| Micronutrient Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran. , z.bahadoran@sbmu.ac.ir |
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Abstract: (126 Views) |
Intermittent fasting (IF) is defined as cycles of complete or significant abstinence from food, followed by designated feeding periods. Intermittent fasting leads to reduction in body weight and fat mass, decreased adipocyte size, enhanced fat metabolism in adipose tissue, improved mitochondrial function in adipocytes, and improved glucose and insulin metabolism. Therefore, IF models have garnered attention as innovative approaches for managing obesity and overweight and improving metabolic profiles; among these, the time-restricted feeding (TRF) model is a particularly popular. TRF involves complete fasting for a specific duration each day (typically 14 to 20 hours) with eating permitted during non-fasting hours. This review discusses the clinical trials findings regarding the impact of TRF on body composition in overweight and obese individuals. It also discusses the synchronization of TRF models with the biological clock and the possible adverse and unfavorable effects of this common model of IF. The results of clinical trials show that adherence to the TRF model is linked to a body weight reduction of 1.2% to 5% (approximately 1.7 to 3.5 kilograms) and a fat mass decrease of 3% to 21% (around 0.5 to 7.0 kilograms) in individuals with obesity or overweight. Factors such as fasting duration, timing of the eating window (early, mid-time, or late of the day), number of meals consumed during this window, and adherence duration may influence the effects of the TRF on weight and body composition. |
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| Keywords: Intermittent fasting, Time-restricted eating, Eating window, Obesity, Overweight |
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Full-Text [PDF 1052 kb]
(122 Downloads)
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Type of Study: Review |
Subject:
Nutrition
Received: 2024/06/29 | Accepted: 2024/08/4 | Published: 2023/12/31
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