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:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 17, Issue 3 (9-2015) ::
2015, 17(3): 230-237 Back to browse issues page
Effect of Hydroalcoholic Extract of Chevil (Ferulago angulata) on Glucose and Lipid in Diabetic Male Rats
Fateme Musavi Ezmareh , Mohamad Mazani , Esfandiar Heidarian , Reza Ali Panah Moghadam , Mahmood Rafieian , Marzie Ebrahimi , Majme Shahinfard , Eslam Ghezel Sofli
Ardabil University of Medical Sciences , m.mazani@arums.ac.ir
Abstract:   (14180 Views)

Introduction: Diabetes is a metabolic disease characterised by chronic hyperglycemia. Considering the properties antioxidant of the Chevil plant compounds, this study performed to determine the effect of hydroalcoholic extract of Chevil on serum glucose and lipid in diabetic male rats. Materials and Methods: In this study, 54 male Wistar rats weighing 200-250 g were divided into 6 groups (n=9 each) and studied for 4 weeks. The groups were as follows: Control, diabetic, diabetic groups treated 200, 400 and 800 mg/kg body weight of the Chevil extract, respectively and the diabetic rats treated with 150 mg/kg body weight of metformin. At the end of study, FBS, Cholesterol, Triglycerides, HDL-C, and LDL-C levels were measured. Results were analyzed by one-way ANOVA. Results: Findings showed a significant reduction (P<0.05) of FBS in all groups with three doses of the extract, 26%, 59.3%, 69.4% respectively), Triglycerides (at 200 and 400 mg/kg of the extract respectively 16.1% and 34.1%), Cholesterol (800 mg/kg of the extract, 20.9%), LDL-C in all three doses of the extract, 25.9%, 49.1% and 53% respectively and a significant increase (P<0.05) in HDL-C in all three doses of the extract, 32.6%, 36.4% and 37.1% respectively compared to the control group was observed in diabetic rats treated with Chevil. Conclusion: The results of this study showed that Chevil extract reduces blood sugar and improves blood lipid profiles in diabetic rats.

Keywords: Diabetes, Blood lipid profiles, Chevil, Alloxan, Male rats
Full-Text [PDF 324 kb]   (2235 Downloads)    
Type of Study: Original | Subject: Biochemistry
Received: 2015/01/8 | Accepted: 2015/06/28 | Published: 2015/09/16
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Musavi Ezmareh F, Mazani M, Heidarian E, Ali Panah Moghadam R, Rafieian M, Ebrahimi M, et al . Effect of Hydroalcoholic Extract of Chevil (Ferulago angulata) on Glucose and Lipid in Diabetic Male Rats. Iranian Journal of Endocrinology and Metabolism 2015; 17 (3) :230-237
URL: http://ijem.sbmu.ac.ir/article-1-1871-en.html


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Volume 17, Issue 3 (9-2015) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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