Effect of Hydroalcoholic Extract of Chevil (Ferulago angulata) on Glucose and Lipid in Diabetic Male Rats
|
Fateme Musavi Ezmareh , Mohamad Mazani , Esfandiar Heidarian , Reza Ali Panah Moghadam , Mahmood Rafieian , Marzie Ebrahimi , Majme Shahinfard , Eslam Ghezel Sofli  |
Ardabil University of Medical Sciences , m.mazani@arums.ac.ir |
|
Abstract: (15066 Views) |
Introduction: Diabetes is a metabolic
disease characterised by chronic hyperglycemia. Considering the properties antioxidant
of the Chevil plant compounds, this study performed to determine the effect of
hydroalcoholic extract of Chevil on serum glucose and lipid in diabetic male
rats. Materials and Methods: In this study, 54 male Wistar rats weighing
200-250 g were divided into 6 groups (n=9 each) and studied for 4 weeks. The
groups were as follows: Control, diabetic, diabetic groups treated 200, 400 and
800 mg/kg body weight of the Chevil extract, respectively and the diabetic rats
treated with 150 mg/kg body weight of metformin. At the end of study, FBS,
Cholesterol, Triglycerides, HDL-C, and LDL-C levels were measured. Results were
analyzed by one-way ANOVA. Results: Findings showed a significant
reduction (P<0.05) of FBS in all groups with three doses of the extract,
26%, 59.3%, 69.4% respectively), Triglycerides (at 200 and 400 mg/kg of the
extract respectively 16.1% and 34.1%), Cholesterol (800 mg/kg of the extract,
20.9%), LDL-C in all three doses of the extract, 25.9%, 49.1% and 53% respectively
and a significant increase (P<0.05) in HDL-C in all three doses of the
extract, 32.6%, 36.4% and 37.1% respectively compared to the control
group was observed in diabetic rats treated with Chevil. Conclusion: The
results of this study showed that Chevil extract reduces blood sugar and
improves blood lipid profiles in diabetic rats. |
|
Keywords: Diabetes, Blood lipid profiles, Chevil, Alloxan, Male rats |
|
Full-Text [PDF 324 kb]
(2420 Downloads)
|
Type of Study: Original |
Subject:
Biochemistry Received: 2015/01/8 | Accepted: 2015/06/28 | Published: 2015/09/16
|
|
|
|
|
Add your comments about this article |
|
|