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:: Volume 17, Issue 3 (9-2015) ::
2015, 17(3): 230-237 Back to browse issues page
Effect of Hydroalcoholic Extract of Chevil (Ferulago angulata) on Glucose and Lipid in Diabetic Male Rats
Fateme Musavi Ezmareh Seyede, Mohamad Mazani Dr. *, Esfandiar Heidarian Dr., Reza Ali Panah Moghadam Dr., Mahmood Rafieian Dr., Marzie Ebrahimi , Majme Shahinfard , Eslam Ghezel Sofli
Associate Professor Ardabil University of Medical Sciences , m.mazani@arums.ac.ir
Abstract:   (3536 Views)

Introduction: Diabetes is a metabolic disease characterised by chronic hyperglycemia. Considering the properties antioxidant of the Chevil plant compounds, this study performed to determine the effect of hydroalcoholic extract of Chevil on serum glucose and lipid in diabetic male rats. Materials and Methods: In this study, 54 male Wistar rats weighing 200-250 g were divided into 6 groups (n=9 each) and studied for 4 weeks. The groups were as follows: Control, diabetic, diabetic groups treated 200, 400 and 800 mg/kg body weight of the Chevil extract, respectively and the diabetic rats treated with 150 mg/kg body weight of metformin. At the end of study, FBS, Cholesterol, Triglycerides, HDL-C, and LDL-C levels were measured. Results were analyzed by one-way ANOVA. Results: Findings showed a significant reduction (P<0.05) of FBS in all groups with three doses of the extract, 26%, 59.3%, 69.4% respectively), Triglycerides (at 200 and 400 mg/kg of the extract respectively 16.1% and 34.1%), Cholesterol (800 mg/kg of the extract, 20.9%), LDL-C in all three doses of the extract, 25.9%, 49.1% and 53% respectively and a significant increase (P<0.05) in HDL-C in all three doses of the extract, 32.6%, 36.4% and 37.1% respectively compared to the control group was observed in diabetic rats treated with Chevil. Conclusion: The results of this study showed that Chevil extract reduces blood sugar and improves blood lipid profiles in diabetic rats.

Keywords: Diabetes, Blood lipid profiles, Chevil, Alloxan, Male rats
Full-Text [PDF 324 kb]   (788 Downloads)    
Type of Study: Original | Subject: Biochemistry
Received: 2015/01/8 | Accepted: 2015/06/28 | Published: 2015/09/16
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Musavi Ezmareh F, Mazani M, Heidarian E, Ali Panah Moghadam R, Rafieian M, Ebrahimi M, et al . Effect of Hydroalcoholic Extract of Chevil (Ferulago angulata) on Glucose and Lipid in Diabetic Male Rats. Iranian Journal of Endocrinology and Metabolism. 2015; 17 (3) :230-237
URL: http://ijem.sbmu.ac.ir/article-1-1871-en.html
Volume 17, Issue 3 (9-2015) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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