[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Last site contents
:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 14, Issue 3 (9-2012) ::
2012, 14(3): 207-214 Back to browse issues page
Effect of Vitamin C Supplementation on Fasting and Postprandial Oxidative Stress, Inflammatory Markers and Lipid Profiles in Type 2 Diabetic Patients
Zohreh Mazloom , Najmeh Hejazi , Mohammad –Hossein Dabbaghmanesh , Hamid-Reza Tabatabaee
Dept. of Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran. , n20hejazi@yahoo.com
Abstract:   (12277 Views)
Introduction: Diabetes mellitus is one of the most wide spread endocrine disorders and among the most important developing health issues. This disease is associated with increased free radical production and decrease in antioxidant defense systems. In this study we evaluated the effect of vitamin C supplementation on fasting and postprandial oxidative stress, inflammatory markers and lipid profiles in type 2 diabetic patients. Materials and Methods: Thirty patients with type 2 diabetes (age range 25 to 65 years) were randomly divided into two groups, 1) treatment with vitamin C (1000mg/d) and 2) the placebo group. They were supplemented for 6 weeks, after which we measured malondialdehyde, IL-6, hs-CRP and lipid profiles in fasting and postprandial state (after a breakfast containing 80g fat, the same as the first day of the study). Data analysis was carried out using Mann Whitney U test, with P<0.05 being significant by SPSS software version 11. Results: Results showed a significant decrease in fasting (p=0.006) and postprandial MDA (p<0.001) in the vitamin C group compared to controls but there were no significant changes in inflammatory markers and lipid profiles in the fasting and postprandial states. Conclusion: This study suggests that short term vitamin C supplementation can decrease fasting and postprandial oxidative stress, and thereby possibly prevent diabetes complications.
Keywords: Type 2 diabetes mellitus, Oxidative stress, Vitamin C, Postprandial state, Malondialdehyde
Full-Text [PDF 294 kb]   (5121 Downloads)    
Type of Study: Original | Subject: Nutrition
Received: 2011/10/2 | Accepted: 2012/04/11 | Published: 2012/09/15
Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

mazloom Z, hejazi N, Dabbaghmanesh M –, Tabatabaee H. Effect of Vitamin C Supplementation on Fasting and Postprandial Oxidative Stress, Inflammatory Markers and Lipid Profiles in Type 2 Diabetic Patients. Iranian Journal of Endocrinology and Metabolism 2012; 14 (3) :207-214
URL: http://ijem.sbmu.ac.ir/article-1-1255-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 14, Issue 3 (9-2012) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.05 seconds with 38 queries by YEKTAWEB 4645