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:: جلد 11، شماره 6 - ( 1-1388 ) ::
جلد 11 شماره 6 صفحات 707-712 برگشت به فهرست نسخه ها
Investigation on the Levels of IGF-I Receptor and IGF-I Binding Protein I in the Brain of Insulin Resistant Rats
دكتر آزیتا پروانه تفرشی، دكتر راضیه جلال، شمیلا درویش علی پور، دكتر حوری سپهری، دكتر خسرو عادلی
، tafreshi@nigeb.ac.ir
چکیده:   (8631 مشاهده)
Abstract Introduction: There is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor (IGF-I) to transduce the signals in different areas of the brain. In this article we aimed at investigating whether the expression of IGF-I receptor and IGF-I binding proteins (IGFBP1) is changed in the brain of the diabetic animal model. Materials and Methods: To induce insulin resistance, adult wistar rats were fed with fructose in their drinking water (10%). The expression of IGF-I receptor and its binding protein were examined immunohistochemically. Results: Our findings demonstrated that the expression of IGF-I receptor and IGF-I binding protein were not changed in different areas of the brain in insulin resistant rats, compared to those in the control rats. Conclusion: The unchanged expression levels of IGF-I receptor and its binding protein I not imply the lack of involvement of the IGF-I signal transduction pathway in the insulin resistant brain, further investigations are to clarify the issue.
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نوع مطالعه: پژوهشی |
دریافت: ۱۳۸۹/۱/۱۹
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Parvaneh Tafreshi A, Jalal R, Darvishalipour S, Sepehri H, Adeli K. Investigation on the Levels of IGF-I Receptor and IGF-I Binding Protein I in the Brain of Insulin Resistant Rats. Iranian Journal of Endocrinology and Metabolism. 2009; 11 (6) :707-712
URL: http://ijem.sbmu.ac.ir/article-1-929-fa.html

پروانه تفرشی آزیتا، جلال راضیه، درویش علی پور شمیلا، سپهری حوری، عادلی خسرو. Investigation on the Levels of IGF-I Receptor and IGF-I Binding Protein I in the Brain of Insulin Resistant Rats. مجله‌ي غدد درون‌ريز و متابوليسم ايران. 1388; 11 (6) :707-712

URL: http://ijem.sbmu.ac.ir/article-1-929-fa.html



جلد 11، شماره 6 - ( 1-1388 ) برگشت به فهرست نسخه ها
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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