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:: Volume 8, Issue 4 (12-2006) ::
2006, 8(4): 345-349 Back to browse issues page
Coexistence of Hyperhomocysteinemia and Protein C Deficiency in the Development of Sinus Thrombosis a Case Report
A Borhan-Haghighi PhD , B Sabaeiyan PhD, M Najabat PhD, G Omrani PhD
, hormone@sums.ac.ir
Abstract:   (16846 Views)
Introduction: Hyperhomocysteinemia is a rare autosomal recessive inherited metabolic disorder. The main clinical manifestations of hyperhomocysteinemia include mental retardation, psychological disturbance, thromboembolic events and skeletal abnormalities. The case reported here is of a 28 year-old man admitted in hospital with recurrent seizures. In the brain MRI, areas of venous infarction were seen and MRA revealed thrombosis in brain venous sinuses. Lab investigation showed increases in serum level of homocystein and protein C deficiency. The patient had no family history of genetic disease or cerebrovascular attack. As sinus thrombosis is a multifactorial disease, Protein C deficiency can be one of aggravating causes of thromboembolic events in patients with hyperhomocysteinemia.
Keywords: Hyperhomocysteinemia, Protein C, Thrombosis, Cerebrovascular attack
Full-Text [PDF 231 kb]   (1889 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2007/05/16
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Borhan-Haghighi A, Sabaeiyan B, Najabat M, Omrani G. Coexistence of Hyperhomocysteinemia and Protein C Deficiency in the Development of Sinus Thrombosis a Case Report . Iranian Journal of Endocrinology and Metabolism. 2006; 8 (4) :345-349
URL: http://ijem.sbmu.ac.ir/article-1-353-en.html


Volume 8, Issue 4 (12-2006) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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