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Metabolic effects of vanadyl sulfate in type 2 diabetic patients
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R Eshtiaghi   , GH Omrani , GHA Dehghani |
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Abstract: (43538 Views) |
| Abstact: There are many studies about the metabolic effect of vanadium salts on STZ- induced diabetic rats. These studies confirmed the effects of this ultra trace element as a insulin-mimetic agent. Vanadyl sulfate had a positive effect on glycemic control and lipid profile in STZ-diabetic rats, according to Mcneill et al & other centers studies. This agent had no adverse effect in any organs. After studies about vanadium salts in human diabetes in Joslin Clinic which declared positive results, we organized our study in NIDDM patients. 45 consecutive series of NIDDM patients groupted into monotherapy (n=35) and combination therapy (n=10) the results showed a significant reduction in BMI only in monotherapy group (27.7±3.6 vs 26.3±3.3), P<0.05 Glycemic control demonstrated 17% decrease in FBS, 2hppG after 6 weeks (P< 0.01). After 3 to 4 months, 27 percent reduction in blood glucose occurred in both groups. Fasting blood glucose (260.9±14.8 mg/dl vs 190.6±13.73) and 2hppG (366.5±21.2 vs 267.3±16.1) decreased (P<0.01). The improvement of HbA1c (1.34%) established long term efficacy of vanadyl sulfate in NIDDM control and potential risk reduction properties (P<0.05). In conclusion, three to four months’ treatment with vanadyl sulfate improves short and long term control of diabetes mellitus. |
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| Keywords: NIDDM, Vanadyl, Vanadium |
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Type of Study: Original |
Subject:
Endocrinology
Received: 2006/11/30 | Published: 2000/12/15
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