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:: Volume 7, Issue 2 (6-2005) ::
2005, 7(2): 167-171 Back to browse issues page
Hypolipidemic effect of aqueous leaf extract of Trigonella foenum-graecum in diabetic rats
M Roghani , T Baluchnejadmojarad , F Roghani Dehlordi
, mehjour@yahoo.com
Abstract:   (21124 Views)
Introduction: Considering the hypoglycemic and hypolipidemic effect of the fenugreek seed and hypoglycemic effect of its leaf, this study was conducted to evaluate the hypolipidemic effect of its aqueous leaf extract. Materials and Methods: Male Wistar rats were divided into control, extract-treated control, diabetic, and extract-treated diabetic groups. Fenugreek extract was administered at doses of 100 and/or 200 mg/Kg (i.p) every other day three days after the induction of diabetes for a period of 2 months. Serum total cholesterol, triglyceride, LDL- and HDL-cholesterol levels were measured one week before the study and again 4 and 8 weeks after the experiment. Results: Serum total cholesterol significantly increased (p<0.05) in diabetic rats, with the extract treatment having no effect in this respect there was a non-significant increase in triglyceride levels in diabetic rats again with no effect of extract treatment. On the other hand, LDL- and HDL cholesterol levels significantly increased (p<0.01) and decreased (p<0.05) in diabetic rats respectively, and administration of the extract significantly (p<0.05 and p<0.01) reversed these changes. Conclusion: The results showed that treatment of diabetic rats with aqueous extract of fenugreek could improve the inappropriate changes in LDL- and HDL-cholesterol and this could reduce the ensuing cardiovascular complications caused by diabetes mellitus.
Keywords: Fenugreek, Diabetes mellitus, Triglyceride, Total cholesterol, LDL, HDL, Rat
Full-Text [PDF 293 kb]   (2333 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2006/11/16
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Roghani M, Baluchnejadmojarad T, Roghani Dehlordi F. Hypolipidemic effect of aqueous leaf extract of Trigonella foenum-graecum in diabetic rats. Iranian Journal of Endocrinology and Metabolism. 2005; 7 (2) :167-171
URL: http://ijem.sbmu.ac.ir/article-1-125-en.html


Volume 7, Issue 2 (6-2005) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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