[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
Main Menu
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Last site contents
:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 12, Issue 5 (2-2011) ::
2011, 12(5): 466-475 Back to browse issues page
Effect of Long-term Continuous Methimazole Treatment of Thyrotoxicosisi: Comparison with Radioiodine
V Yousefi , H Bahreynian , F Sheykholeslami , M Tohidi , Y Mehrabi , F Azizi
Abstract:   (67122 Views)


Introduction: The major complication of radioiodine therapy for thyrotoxicosis is hypoth-yroidism, the long-term management of which is often problematic. In this study, the long-term effects of continuous methimazole (MMI) therapy are investigated. Materials and Methods: One hundred and thirty-two patients, aged between 36-66 years, with Graves recurrence, were semi randomly randomized in 2 groups for continuous antithyroid and radioiodine treatment. The number of thyroid dysfunctions in each patient were recorded and serum TSH, FT4, Anti TPO, TRAb, FBS, HOMA IR, and lipid profiles were measured. Bone mineral density and echocar-diography were performed. Results: There was no significant differences in age, duration of symptoms and thyroid function between the 2 groups. No serious complications occurred in the MMI group and no difference in any of parameters was seen between groups 1 and 2. Goiter rate and anti TPO concentration were higher in group 1 than in group 2. Serum triglycerides and cholesterol were increased in group 2 as compared to group 1. Bone mineral density was more reduced in group 2, especially in the spine. Echocardiography showed diastolic dysfunction in group 2 as compared to group 1. Some parameters in neuro-pschyciatric evaluation were significantly better in the MMI group, as compared to the radioiodine one. Conclusion: Considering it is a safe treatment and has fewer complications, methimazole is another option for patients with recurrent Graves', who do not wish to use radioiodine.

Keywords: Methimazole, Radioiodine, Hyperthyroidism, Recurrence, Complications
Full-Text [PDF 320 kb]   (13634 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2010/07/13 | Published: 2011/02/15
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

yousefi V, Bahreynian H, Sheykholeslami F, Tohidi M, Mehrabi Y, Azizi F. Effect of Long-term Continuous Methimazole Treatment of Thyrotoxicosisi: Comparison with Radioiodine . Iranian Journal of Endocrinology and Metabolism 2011; 12 (5) :466-475
URL: http://ijem.sbmu.ac.ir/article-1-994-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 12, Issue 5 (2-2011) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.05 seconds with 38 queries by YEKTAWEB 4657