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:: Volume 7, Issue 4 (12-2005) ::
2005, 7(4): 365-373 Back to browse issues page
Evaluation of HDL-C determination methods
M Hedayati , MS Daneshpour
, hedayati@erc.ac.ir
Abstract:   (20470 Views)
Following confirmation of the role of HDL-C role in cardiovascular disease, its measurement has become a fixed requirement by physicians. Today serum HDL-C is measured using different methods from simple outdated precipitation methods to the latest of homogenous assays used for HDL-C determination. However, the precision, accuracy and performance, standardization, and evaluation for those methods are controversial. This paper briefly discusses the methodology of various HDL-C determination methods e.g ultra centrifugation, electrophoresis, precipitation and homogenous assays, and advantages of homogenous methods. Human expertise, time consuming and high cost instrumentation of ultra centrifugation, quantitative electrophoresis, nuclear magnetic resonance and chromatographic methods are key factors that make the methods undesirable for clinical laboratories. Precipitation and manual separation steps of non homogenous HDL-C determination methods, reduces their precision, and causes them to be replaced by more precise methods such as homogenous assays however more time is needed for their costs to be more competitive.
Keywords: Evaluation, HDL-C, Determination.
Full-Text [PDF 332 kb]   (3069 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2006/11/15
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Hedayati M, Daneshpour M. Evaluation of HDL-C determination methods. Iranian Journal of Endocrinology and Metabolism. 2005; 7 (4) :365-373
URL: http://ijem.sbmu.ac.ir/article-1-93-en.html


Volume 7, Issue 4 (12-2005) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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