Introduction: Diabetes mellitus is a heterogenous group of different metabolic disorders, characterized by chronic increase of blood glucose and proteins, lipids and carbohydrates. Materials and Methods: In this semi-experimental investigation, 17 women patients with type 2 diabetes from the clinic of the Arak Petroleum Company were selected and divided into two groups: the strengthening (9 persons) and the controls (8 persons). The strengthening group performed selected exercises for 8 weeks (3 sessions/week and 30-50 min/session). In this investigation we assessed metabolic factors (total cholesterol, triglycerides, HDL, VLDL, LDL, FBS, HbA1c and Insulin Serum) and compared SF-36 and GHQ questionnaires. Data analyses was performed with SPSS.12 and we used of the paired samples T test. Confidence level was considered at 95% (P<0.05). Results: There were significant differences between means of pre-test and post-test measures of TC, FBS, HbA1C, insulin serum,  quality of life (QOL) and mental health (MH) of the strengthening group, but no significant differences were found between means of pre-test and post-test measures of HDL, LDL, VLDL and triglycerides in the strengthening group and factors of control group (P<0.05). Conclusion: It seems that strengthening exercises are an effective treatment for metabolic factors, QOL and MH in type 2 diabetic patients, and lead to improvement in the patient's status.