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Reproductive Hormonal Changes Following Two Types of Hypocaloric Diets in Overweight and Obese Polycystic Ovary Syndrome Women
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Homeira HamayeliMehrabani   , Farideh Tahbaz , Saghar Salehpour , Mehdi Hedayati , Zohreh Amiri , Atusa Ghasemi |
| , farideh.tahbaz@gmail.com |
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Abstract: (35672 Views) |
| Introduction: The appropriate combination and composition of hypocaloric diets for obese women with polycystic ovary syndrome (PCOS) is still unclear. The aim of this study was to investigate the effects of a high protein-low glycaemic load diet on reproductive hormones in obese women with PCOS. Materials and Methods: In this single blind clinical trial, sixty overweight and obese women with PCOS, not using metformin, were randomly assigned in one of two groups, the modified with a 30% protein-low glycaemic load diet, and the conventional with 15% protein. Reproductive hormones, glucose and insulin were measured for 49 subjects at baseline and after 12 weeks. Results: Weight loss showed no significant difference in the two groups. Changes in means for testosterone in the modified and conventional groups (0 to 12 weeks), were 1.78±1.52 to 1.31±1.27 and 1.51±0.63 to 1.15±0.57 ng/ml, respectively (p<0.001). FSH, LH, estradiol, progesterone and prolactin did not change. Insulin and HOMA reduction was significant for modified diet (p<0.001). Conclusion: Weight loss had a significant effect on reduction of androgens. The main effect of modified diet with high protein and low glycaemic load was observed on insulin and HOMA, a finding which should taken into consideration for women with PCOS. |
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| Keywords: PCOS, Weight loss, Hypocaloric diet, Obesity, Reproductive hormones |
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Full-Text [PDF 308 kb]
(5084 Downloads)
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Type of Study: Original |
Subject:
Nutrition
Received: 2009/10/1 | Accepted: 2014/05/24 | Published: 2014/05/24
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