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Screening for congenital hypothyroidism: before and after iodine supplementation in Iran
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A Ordoukhani   , AA Mirsaiid Ghazi , R Hajipour , P Mirmiran , M Hedayati , F Azizi |
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Abstract: (38883 Views) |
| Abstract: Screening program for congenital hypothyroidism (CH) started in 1987 and had to be discontinued due to high prevalence rate of hyperthyrotropinemia in infants and subsequent increased recall rate. Recent surveys denote that more than 95% of Iranian households consume iodized salt, and nationwide measurement of urinary iodine concentration in schoolchildren showed absence of iodine deficiency. The present study compares CH screening results before and after iodine supplementation. In 1987-89, serum TSH concentration was measured in 1724 cord blood specimens and in 1998-99, TSH (IRMA) was measured in cord blood filter paper specimens of 2936 newborns. Those with TSH≥20mU/L were recalled and thyroid function tests were performed, using venous blood. Newborns were calssified into 3 groups according to TSH concentrations: 0-9.9, 10-19.9, and ≥ 20mU/L. In 1987-89, 81% and 14% and in 1998-99, 83.9% and 14.5% of the newborns had TSH values between 0-9.9 and 10-19.9 mU/L, respectively (p=NS). Corresponding values for TSH≥20mU/L were 5% and 1.6%, respectively (P<0.001). In 1997-98, 0.8%, 0.3% and 0.1% of all newborns had TSH values between 25.1-50, 35.1-50, and >50mU/L, respectively. Iodine sufficiency in I.R. Iran has caused significant decrease in neonatal hyperthyrotropinemia and recall rate of screening program for CH. |
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| Keywords: Hypothyroidism, Screening, Iodine deficiency |
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Full-Text [PDF 251 kb]
(4710 Downloads)
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Type of Study: Original |
Subject:
Endocrinology
Received: 2006/11/14 | Published: 2000/06/15
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