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Correlation between βhCG level and thyroid function tests in molar pregnancy
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F Salavatian   , B Aminian , GH Omrani |
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Abstract: (30779 Views) |
| Abstract: In view of controversy regarding the role of human chorionic gonadotropin (hCG) as the stimulator of thyroid function in patients with trophoblastic tumors, especially hydatidiform mole, we conducted a study to explore whether a correlation between human chorionic gonadotropin and thyroid function is demonstrable in such patients. Forty-eight patients with hydatidiform mole, who had a drop in serum βhCG concentration below 5 mIU/ml during a period of eighteen months after evacuation, were selected. Serum βhCG, total T3, total T4 and serum TSH were measured both when βhCG was high and when it dropped to below 5 mIU/ml. Serum βhCG, total T3, and total T4 were measured with radioimmunoassay. The human TSH-coated tube assay was utilized for immunoradiometric assay of TSH. Among forty-three patients with βhCG concentrations exceeding 100 mIU/ml, total T4 values were higher than 8.8 μg/dl in thirty patients. The regression equation between total T4 and high βhCG levels was 6.36 with a P value of 0.00. The regression equation between FT4I and high βhCG level was 2.105 (P=0.002). The regression equation between high T3 and FT3I and high levels of βhCG was 133.39 and 37.3 respectively (P=0.026 and 0.024). The mean value of TSH was 0.9915 mIU/ml before and 1.533 mIU/ml after treatment. The regression equation between TSH and βhCG was 1.8448 (P=0.044). This study shows a strong correlation between high serum βhCG and total serum T4 and FT4I. There is also a correlation between high serum βhCG and total T3 and FT3I. There is a weak statistical correlation between high serum βhCG and low serum TSH. |
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| Keywords: Human chorionic gonadotropin, Hydatidiform mole, Thyroid function tests |
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Full-Text [PDF 255 kb]
(3876 Downloads)
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Type of Study: Original |
Subject:
Endocrinology
Received: 2006/11/14 | Published: 2000/06/15
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