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Comparison of the effect of an Iranian brand of Simvastatin (Simvastatin, Shahre Daroo) with a foreign brand, Zocor
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P Heydarian   , J Ghanbili , H Emami , F Azizi |
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Abstract: (25918 Views) |
| Abstract: To compare the effects of two brands of Simvastatin, Simvastatin (Shahre Daroo) and Zocor (Merck Sharp & Dohme), 20 hyperlipidemic patients (14 women, 6 men) with a mean age of 53.9±9.4 years, being candidates for drug therapy based on National Cholesterol Education Program guidelines and having no contraindications for using “statin”, were randomly assigned to treatment with Simvastatin (11 patients) or Zocor (9 patients), 20 mg to be taken before the evening meal. The mean basal total cholesterol and LDL cholesterol of patients were 326±38 mg/dl and 245±47 mg/dl, respectively. The patients were visited 4 and 8 weeks after treatment to repeat clinical and laboratory exams. There were no significant differences between the treatment groups in the male to female ratio, mean age, mean basal lipid levels and attending follow up. Four weeks after treatment, Simvastatin reduced total cholesterol by 24.9% ± 4.8 (83 ± 54 mg/dl, P<0.001) and Zocor reduced it by 24.9% ± 3.8 (81 ± 38 mg/dl, P<0.001). Almost all of the difference in total cholesterol at 4 weeks was due to the reduction in LDL cholesterol, 34.2% ± 5.5 (85 ± 47 mg/dl, P<0.001) and 32% ± 4.8 (79 ± 39 mg/dl, P<0.001) in the Simvastatin and Zocor groups respectively. Eight weeks after treatment, Simvastatin reduced total cholesterol by 26.8% ± 4.3 (87 ± 39 mg/dl, P<0.01) and Zocor reduced it by 24.4% ± 3.3 (77 ± 28 mg/dl, P<0.01). Almost all of the difference in total cholesterol at 8 weeks was due to the reduction in LDL cholesterol, 34.6% ± 4.3 (82 ± 29 mg/dl, P<0.001) and 27.8% ± 6.5 (65 ± 42 mg/dl, P<0.05) in the Simvastatin and Zocor groups respectively. Changes in HDL cholesterol and triglycerides were not significant after 4 and 8 weeks of treatment in any group. There were no significant differences between the treatment groups in the changes of any lipid levels. This study shows that Simvastatin (Shahre Daroo) produces similar reductions in total cholesterol and LDL cholesterol as Zocor. |
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| Keywords: Hyperlipidemia, Hyper cholesterolemia, Lipid-lowering drugs, Simvastatin |
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Full-Text [PDF 313 kb]
(6543 Downloads)
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Type of Study: Original |
Subject:
Endocrinology
Received: 2006/11/14 | Published: 2000/03/15
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