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Estrogen and progestin receptors in human breast carcinoma 140 cases
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S Tabei   , M Ashraf |
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Abstract: (32275 Views) |
| Abstract: Breast carcinomas with steroidal receptors and good response to hormonal therapy have better prognosis than those without steroid receptors. This study was to evaluate the association between estrogen and progesterone receptors and the age of patients with the type and severity of malignancy in 140 cases with breast carcinoma between 1997 to 1999 in Shiraz University of Medical Sciences affiliated hospitals. Immunocytochemical method on paraffin fixed sections was used for the evaluation in this study. The prevalence of positive esterogen and progestin receptors in cases aged under 50ys (95 subjects) and over 50ys (45 subjects) were (%46, %41) and (%44, %48), respectively. The highest and lowest positivity of receptors were due to lobular carcinoma (%66.7) and medullary carcinoma (%21.4), respectively. The prevalence of streroid receptors had inverse association with higher grades of differentiated ductal carcinoma (114 cases). However, immunocytochemical estrogen and progestin assay in breast cancer is a reliable method to estimate the prognosis and to make decision for hormonal therapy. |
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| Keywords: Breast cancer, Estrogen receptor, Progesterone receptors, Hormone therapy |
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Full-Text [PDF 218 kb]
(29058 Downloads)
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Type of Study: Original |
Subject:
Endocrinology
Received: 2006/11/14 | Published: 2000/03/15
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