[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
Main Menu
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Last site contents
:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 10, Issue 5 (1-2009) ::
2009, 10(5): 519-526 Back to browse issues page
The Effect of Exercise on Plasma Acylated Ghrelin Concentrations and Gastrocnemius Muscle mRNA Expression in Male Rats
R. Fathi , A Ghanbari-Niaki , F Rahbarizadeh , M Hedayati , E Ghahramanloo , Z. Farshidi
, ghanbara@yahoo.ca
Abstract:   (28805 Views)


Introduction: Ghrelin is a gut hormone predominantly produced by the stomach and, to a lesser extent, by other regions of the gastrointestinal tract. Ghrelin circulates in the bloodstream in two different forms: acylated (or n-octanoylated) and unacylated (or des-octanoylated or des-acylated). The purpose of this study was to examine the effect of 12 weeks training on plasma acylated ghrelin concentrations and gastrocnemius muscle mRNA expression in male rats. Materials & Methods: Twenty adult Wistar male rats (8 weeks old, 280±20 g) were used. Animals were randomly divided into experimental (EX, n = 10, V=34m/min) and control (n=10) groups. Training groups were given exercise on a motor-driven treadmill (0% grade, 60min, and 5 days/week for 12 weeks). Gastrocnemius was excised and frozen in liquid nitrogen for extraction of ghrelin mRNA and plasma acylated ghrelin, were measured. Results: Plasma acylated ghrelin was significantly (P<0.01) higher in high intensity trained rats. Also muscle mRNA expression was higher in trained rats compared to control rats. Conclusion: Data indicate that higher ghrelin mRNA expression in muscle and higher plasma acylated ghrelin levels could be attributed to metabolic changes (muscle glycogen and ATP depletion are less in endurance trained species). A higher plasma acylated ghrelin in the present study might be attributed to liver and skeletal muscle glycogen and ATP deficiency and incomplete energy sources recovery after the last exercise session along with overnight fast. Lower muscle glycogen levels, as we observed in the present study, might be considered as stimuli for this elevated plasma acylated ghrelin in trained rats.

Keywords: Acylated ghrelin, High intensity training, Gastronomies muscle, Glycogen, Rat.
Full-Text [PDF 330 kb]   (4531 Downloads)    
Type of Study: Original |
Received: 2009/02/5 | Published: 2009/01/15
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fathi R, Ghanbari-Niaki A, Rahbarizadeh F, Hedayati M, Ghahramanloo E, Farshidi Z. The Effect of Exercise on Plasma Acylated Ghrelin Concentrations and Gastrocnemius Muscle mRNA Expression in Male Rats. Iranian Journal of Endocrinology and Metabolism 2009; 10 (5) :519-526
URL: http://ijem.sbmu.ac.ir/article-1-627-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 5 (1-2009) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.05 seconds with 37 queries by YEKTAWEB 4624