[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
:: Volume 8, Issue 1 (3-2006) ::
2006, 8(1): 91-96 Back to browse issues page
Effect of acute and and chronically administrated estradiol benzoate on the withdrawal syndrome in morphine dependent ovariectomized mice
M Kesmati, HR Namayandeh
, kesmatim@cua.ac.ir
Abstract:   (22182 Views)
Introduction: There is some evidence about the role of estrogen in the nervous system such, as increasing plasticity in different areas of brain and interference phenomena like reproduction, pain and memory. Results of some investigation indicate the neuromodulatory effect of estrogen. In this study, the effect of estradiol benzoate in morphine dependency was investigated. Material and Methods: Albino mice weighing 25±3 grams, were divided to in to control (sham operation), ovariectomized, ovariectomized receiving sesame oil and acute and chronically administrered estradiol benzoate groups. Addiction was induced in all animals by morphine injections 3 times per day, for four days. On the fourth day, half an hour before induction of withdrawal syndrome naloxone, stradiol benzoate were acutely injected (0.1 mg/kg, SC) and jumping of animals as a sign of withdrawal syndrome was assessed. Chronic treatment of estradiol benzoate was co-administered with morphine on four the day. Results: The results showed that ovarectomy decreased jumping activity of withdrawal syndrome or intensity of morphine-dependency and estradiol benzoate treatment partially increased this sign of the withdrawal syndrome although but it was less than the control groups. Conclusion: The results suggest that the other sex related factors probably influence the intensity of morphine dependency.
Keywords: Estradiol, Morphine, Withdrawal Syndrome, Ovariectomy
Full-Text [PDF 196 kb]   (2486 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2006/11/12 | Published: 2006/03/15
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kesmati M, Namayandeh H. Effect of acute and and chronically administrated estradiol benzoate on the withdrawal syndrome in morphine dependent ovariectomized mice. Iranian Journal of Endocrinology and Metabolism. 2006; 8 (1) :91-96
URL: http://ijem.sbmu.ac.ir/article-1-61-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 8, Issue 1 (3-2006) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.07 seconds with 31 queries by YEKTAWEB 4419