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Thyroid Autoimmunity disorders in Patients with Chronic Hepatitis C, before Interferon therapy
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SM Alavian   , SH Assari , H Manzouri Jooibari , AH Mohammad Alizadeh |
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Abstract: (32666 Views) |
| Introduction: Several researchers believe that thyroid autoimmunity is more prevalent in patients with hepatitis C than in the general population, however this is still a controversial issue. The aim of the current study was to determine 1) the frequency of thyroid autoantibodies, 2) the frequency of thyroid dysfunction, 3) correlation of thyroid autoantibodies and dysfunction with demographic and clinical variables, in patients with chronic hepatitis C. Materials and Methods: This cross-sectional study was conducted on 250 patients with chronic hepatitis C patients were selected by simple non sampling from patients referring to the Tehran Hepatitis Center in 2003 and 2004. Demographic data (age, sex, educational level, job) and clinical variables (including risk factors, liver enzymes, liver histopathology, HCV RNA viral load), were obtained. Anti Thyronin (TPO Ab, 124), Anti thyroglobulin (TG Ab, n=117), TSH (n=239), T3 (n=242), T4 (n=245), T3RU (n=134) was tested. Results: TPO Ab and TG Ab were seen in 4% and 3.4% respectively. 1.2% had the history of thyroid diorders. 4 subjects had thyrotoxicosis, 1 subject had Hashimoto thyroiditis, 3 subjects had subclinical hyperthyroidisem, and 5 patients had subclinical hypothyroidisem. Positive TPO Ab had a statistical correlation that was marginally significant correlation with cirrhosis, physical symptoms and history of traditional phlebotomy (0.05
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| Keywords: Hepatitis C- Autoimmunity – Thyroid disorders- Anti thyroperoxidase antibody- anti thyroglobulin antibody |
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Full-Text [PDF 266 kb]
(3101 Downloads)
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Type of Study: Original |
Subject:
Endocrinology
Received: 2006/11/11 | Published: 2006/03/15
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