[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
Main Menu
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Last site contents
:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 9, Issue 4 (3-2008) ::
2008, 9(4): 423-427 Back to browse issues page
Effect of Cannabis Sativa L. (Isfahan Variety) Powder on Serum Lipid Profile in Male Rats
Abstract:   (19051 Views)
Introduction: Hemp is considered a nutritional and narcotic plant whole hempseed has almost 3% saturated fatty acids and 28% unsaturated fatty acids. This study aimed at evaluating the effect of hempseed on lipid profiles of male rats. Materials and Methods: After acclimatization, at the beginning of the experiment (day 0) animal feeding was stopped and after 14h fasting the animal was anesthetized by ketamine/xylazine combination and 2ml a heart sample blood was taken. The rats were fed normal diet (modified AIN-93M pellet) and 5g/Kg of hempseed powder solution (HPS 40%) via gavages daily for 30 days and at the end of experiment (day 31) blood samples were taken again. The lipid parameters were measured by enzymatic-colorimetric techniques. Results: In spite of ω3, ω6 unsaturated fatty acids that are highly present in hempseed, short term hempseed feeding of hempseed additive in male rats did not improve lipid profile the mean fasting serum triglyceride, total cholesterol, LDL-C levels increased, while the mean fasting HDL-C decreased. In fact, no (p<0.05) statistical significant changes were observed in levels of the above mentioned parameters. Conclusion: Obviously the Isfahanian variety of the Cannabis plant has high content of an orexigenic, narcotic component (Tetrahydrocannabinol: THC), which does not alter the lipid profiles of rats if used over a long time it may lead to development of dyslipidemia.
Keywords: Hempseed, Lipid profile, Male rat, Tetrahydrocannabinol
Full-Text [PDF 259 kb]   (5583 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2008/05/14 | Published: 2008/03/15
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Effect of Cannabis Sativa L. (Isfahan Variety) Powder on Serum Lipid Profile in Male Rats. Iranian Journal of Endocrinology and Metabolism 2008; 9 (4) :423-427
URL: http://ijem.sbmu.ac.ir/article-1-471-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 9, Issue 4 (3-2008) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.05 seconds with 38 queries by YEKTAWEB 4652