[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
Main Menu
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Last site contents
:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 9, Issue 4 (3-2008) ::
2008, 9(4): 365-373 Back to browse issues page
The Association between Vitamin D and Bone Mineral Density in Postmenopausal Women
F Hosseinpanah , M Rambod , HR Ghafari , F Azizi
, : fhospanah@ endocrine.ac.ir
Abstract:   (52860 Views)
Abstract Introduction: There are inconsistent data regarding the role of vitamin-D in determining bone mineral density (BMD) especially in less severe vitamin-D deficiency. The aim of this study was to investigate the possible association between 25(OH)D and BMD in healthy free-living postmenopausal women in a population-based study. Materials and Methods: We enrolled 245 postmenopausal women, aged between 40 to 80 years, randomly selected from the Tehran Lipid and Glucose Study. Measurements of BMD were taken at the lumbar spine and upper femur by dual X-ray absorptiometry additional to demographic and anthropometric data, serum 25(OH)D, PTH, calcium, phosphorus and alkaline phosphatase were measured according to the currently used laboratory methods. Bivariate and multivariate analyses were used to explore the association between 25(OH)D, BMD and other clinical and biochemical variables. Results: Mean age and duration of menopause were 58±7 and 9.4±6.8 years, respectively 25(OH)D (29.3±24.9 ng/ml) was <10 ng/ml and 11-20 ng/ml in 5.2% (n=13) and 37.6% (n=92) of women, respectively 25(OH)D correlated inversely with LnPTH (r=-0.25, p<0.01). However no association was found between 25(OH)D level and BMD at any of the skeletal scanning sites in bivariate analysis or multiple linear regression analyses, after adjusting for age, years since menopause, body mass index (BMI), calcium and LnPTH. In the multivariate analyses, BMD correlated inversely with LnPTH, in addition to age and BMI (R2=20%, p=0.03) only in femoral neck, but not at any other sites. Conclusion: This study showed no association between 25(OH)D and BMD in postmenopausal women.
Keywords: Vitamin D, Bone mineral density, Parathormone (PTH), Postmenopausal women, Osteoporosis
Full-Text [PDF 314 kb]   (6796 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2008/05/13 | Published: 2008/03/15
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hosseinpanah F, Rambod M, Ghafari H, Azizi F. The Association between Vitamin D and Bone Mineral Density in Postmenopausal Women. Iranian Journal of Endocrinology and Metabolism 2008; 9 (4) :365-373
URL: http://ijem.sbmu.ac.ir/article-1-461-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 9, Issue 4 (3-2008) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.05 seconds with 38 queries by YEKTAWEB 4652