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:: Volume 9, Issue 3 (12-2007) ::
2007, 9(3): 229-234 Back to browse issues page
Effects of Purified Omega –3 Fatty Acids in Postmenopausal Women with Type 2 Diabetes
F. Shidfar , SH. Yarahmadi , M. Jalali , MH Eftekhari , SH. Hosseyni , L. Ahari
, farzadshidfar @yahoo.com
Abstract:   (37102 Views)
Introduction: Omega 3 fatty acid (03FA) consumption has been shown to reduce risk factors for cardiovascular disease. TYPE 2 diabetes confers an adverse cardiovascular risk profile particularly in women after menopause. The aim of this study was to determine whether a dietary supplement with omega 3 fatty acids affected insulin resistance, glycemic control and cardiovascular risk markers in postmenopausal women with type 2 diabetes. A total of 32 postmenopausal overweight women with diet-controlled type 2 diabetes completed a randomized double blind parallel trial of purified omega 3 fatty acid supplementation (2g/day) versus placebo for 10 weeks. Evaluated were serum triglycerides (TG), HDL-c, total cholesterol (TC) and glucose using the enzymatic method, Insulin by radioimmunoassay and insulin resistance using the Homeostasis Model Assessment method (HOMA-IR) were calculated. Relative to those in the placebo group, TG decreased significantly (P=0.03) in the 03FA group. 03FA supplementation had no significant effect on serum LDL-c, HDL-c , glucose and insulin resistance but there was a significant increase in serum insulin and TC in the 03FA group at the end of study compared to the beginning (P=0.04, P=0.04 respectively). Intake of 2g 03FA had favorable effects on serum TG and TG/HDL-C, no effect of LDL-C, HDL-C, glucose and insulin resistance but did have an adverse effect on serum insulin and TC. Recommendation of 03FA intake in diabetic postmenopausal women needs further investigation.
Keywords: Omega –3 fatty acids, Postmenopausal Women, Type2 Diabetes, Lipoprotein, Glucose
Full-Text [PDF 291 kb]   (2343 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2008/01/16
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Shidfar F, Yarahmadi S, Jalali M, Eftekhari M, Hosseyni S, Ahari L. Effects of Purified Omega –3 Fatty Acids in Postmenopausal Women with Type 2 Diabetes. Iranian Journal of Endocrinology and Metabolism. 2007; 9 (3) :229-234
URL: http://ijem.sbmu.ac.ir/article-1-428-en.html


Volume 9, Issue 3 (12-2007) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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