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:: Volume 9, Issue 2 (IJEM Vol 9, No. 2 2007) ::
2007, 9(2): 201-204 Back to browse issues page
Evaluation of Serum Levels of IL-1α, TGF-β, TNF-α, IFN-α, IFN-γ, Cortisol and Immunoglobulins in Islamic Ramadan Fasting
F. Sharifi, A. Masoud , M. Rezai, M. Ziaei, M. Hedayati
, masood2002@yahoo.com
Abstract:   (28070 Views)
Introduction: This research aimed determining the levels of cortisol, immunoglobulins and major serum cytokines, following Ramadan fasting, as immune response indexes. Materials and Methods: For this before and after Ramadan fasting study, twenty-five students residing at the dormitory of the Tehran University of Medical Sciences were selected. All cytokines levels (IL-1α, TGF-β, TNF-α, IFN-α, IFN-γ) were determined by the ELISA method, Immoglobulines were determined by the Radial Immunodiffusion (SRID) technique and cortisol levels were measured by EIA too. Results: While IFN-γ a showed a considerable increase after Ramadan fasting (P<0.01), IFN-α and TNF-α had decreased (P³ 0.5 and <0.02 respectively). Serum level of TGF-β increased but not significantly (P>0.3) cortisol also increased after one month of fasting (P<0.05). Serum IL-1α had a non-significant decrease (P ³ 0.5). Although IgG & IgM levels showed no significant increase, IgA levels showed significant decrease [P<0.5]. Conclusion: Our data revealed that Ramadan fasting increased IFN-y, while decreasing TNF-a and IgA levels ramadan fasting can probably increase T-Cell function, lower the inflammatory appreance rate and affect immunoglubulin production
Keywords: Islamic Ramadan Fasting, Cytokine, Cortisol, Immunoglobuline
Full-Text [PDF 256 kb]   (3035 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2007/10/20
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Sharifi F, Masoud A, Rezai M, Ziaei M, Hedayati M. Evaluation of Serum Levels of IL-1α, TGF-β, TNF-α, IFN-α, IFN-γ, Cortisol and Immunoglobulins in Islamic Ramadan Fasting. Iranian Journal of Endocrinology and Metabolism. 2007; 9 (2) :201-204
URL: http://ijem.sbmu.ac.ir/article-1-405-en.html


Volume 9, Issue 2 (IJEM Vol 9, No. 2 2007) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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