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:: Editorial Board
:: About Iranian Journal of Endocrinology and Metabolism
:: Volume 9, Issue 2 (IJEM Vol 9, No. 2 2007) ::
2007, 9(2): 171-175 Back to browse issues page
Study of Interaction Between Oxytocin and Opioid System in Locus Coeruleus on Acute Pain in the Rat
M. Kesmati , N. Haghighi , M. Zadkarami
, mahnazkessmati@yahoo.com
Abstract:   (25205 Views)
Introduction: Studies show that the plaus a role hormone oxytocin in the control of pain, sexual behavior, anxiety and love. The mechanism of this neuropeptide is not completely understood in the CNS. This study aimed at researching the effect of oxytoxin administered in the locus coeruleus (LC) nucleus on pain and its interaction with opioid system, because LC influences the nociception and also contains oxytocin and opioid receptors. Materials and Methods: Male wistar rats weighing 270±20 grams were used. Animals divided to the in control group, receiving only oxytocin (3nmol/2µl) and the group receiving oxytocin (3nmol/2µl) with naloxone as an opioid receptor antagonist (3nmol/1µl) in LC nucleus. Hot plate and tail flick tests were used for pain response evaluations. Results: Oxytocin injection in locus coeruleus nucleus induced analgesic effect significantly in two analgesiometer tests (p<0.001). Naloxone prevented the analgesic effect of oxytocin significantly (Hot plate p<0.001, Tail flick p<0.05). Conclusion: Oxytocin exerts part of its antinociception effect via LC nucleus and probably by excitation of the opioid system because of the inhibiting effect of naloxone.
Keywords: Pain, Opioid system, Oxytocin, Locus coeruleus nucleus
Full-Text [PDF 278 kb]   (4711 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2007/10/20 | Published: 2007/09/15
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Kesmati M, Haghighi N, Zadkarami M. Study of Interaction Between Oxytocin and Opioid System in Locus Coeruleus on Acute Pain in the Rat. Iranian Journal of Endocrinology and Metabolism 2007; 9 (2) :171-175
URL: http://ijem.sbmu.ac.ir/article-1-400-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 9, Issue 2 (IJEM Vol 9, No. 2 2007) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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