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Association of Novel Blood Cell-Derived Inflammatory Indices with Metabolic Syndrome
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M Norouzian    , M Teremmahi Ardestani , A Ahmadi , Sh Rafati , N Khaghanzadeh |
| Department of Laboratory Sciences, School of Allied Medical Sciences, Hormozgan University of Medical Sciences, Bandar Abbas, Iran, & Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran, , marzieh.norouzi@gmail.com |
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Abstract: (7 Views) |
Introduction: Metabolic syndrome is associated with an increased risk of cardiovascular disease and diabetes, and inflammation plays an important role in its pathophysiology. This study aimed to investigate the association of novel inflammatory markers derived from blood cells with metabolic syndrome. Materials and Methods: In this cross-sectional study, 2423 participants from the Bandar Kong cohort (453 individuals with metabolic syndrome and 1970 healthy individuals) were studied. Metabolic syndrome was diagnosed based on the NCEP ATP III criteria. The following blood cell–derived inflammatory indices were calculated: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to- high-density lipoproteins ratio (MHR), neutrophil-to- high-density lipoproteins ratio (NHR), and lymphocyte-to-HDL ratio (LHR). Nonparametric tests and logistic regression were used for analysis. Results: The group with metabolic syndrome showed higher levels of NLR, MHR, NHR, and LHR (P=0.03, P<0.001, P<0.001, and P<0.001, respectively) compared to healthy subjects. In logistic regression analysis, hemoglobin (OR=1.236, 95% CI: 1.051–1.454, P=0.01), LHR (OR=4.027, 95% CI: 3.314–6.569, P<0.001), and NHR (OR=5.227, 95% CI: 3.330–7.728, P<0.001) were identified as independent factors associated with metabolic syndrome. Among the components of metabolic syndrome, NHR and LHR showed significant associations with central obesity, hypertension, and low high-density lipoproteins (HDL) levels. Conclusion: The findings of this cross-sectional study suggest that the LHR and NHR indices are associated with metabolic syndrome. These readily available indices may reflect inflammatory status and underlying metabolic disturbances. However, determining the direction of causality and the clinical applicability of these findings requires investigation in prospective studies. |
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| Keywords: Metabolic Syndrome, Inflammatory Indices, Lymphocyte-to-HDL Ratio, Hemoglobin, Neutrophil-to-HDL Ratio |
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Type of Study: Original |
Subject:
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Received: 2025/12/6 | Accepted: 2026/02/9 | Published: 2026/04/30
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