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Investigation of the Incidence of Congenital hypothyroidism and Its Associated Factors in Lorestan Province from 1400 to 1402
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N Zamani    , E Nourizadeh , M Aghamirzaei , M Daraei , M Navabi |
| Department of Biology, School of Science, Payame Noor University, Tehran, Iran. , na_zamani2000@pnu.ac.ir |
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Abstract: (108 Views) |
Introduction: Congenital hypothyroidism, characterized by a deficiency of thyroid hormone at birth, is one of the most common endocrine disorders in infants. The present study aims to investigate the incidence of hypothyroidism and some associated factors in newborns in Lorestan Province. Materials and Methods: This retrospective descriptive study was conducted on newborns born from the first of Farvardin 1400 to the end of Esfand 1402 in Lorestan Province who participated in the newborn screening program for hypothyroidism. Data were collected from the screening forms and analyzed using statistical tests at the 5% significance level. Results: Out of 73,443 screened newborns, 4,771 infants (6.5%) were recalled for further evaluation. The incidence of congenital hypothyroidism during the study period was 6.3 per 1,000 live births, which increased from 5.2 per 1,000 in 1400 to 7.1 per 1,000 in 1402. This increase in 1401 (P=0.03) and 1402 (P=0.008) compared to 1400 was statistically significant. Additionally, the average thyroid stimulating hormone (TSH) level increased significantly during the study period (P<0.001). Furthermore, the incidence of hypothyroidism in male infants was significantly higher than in female infants (male-to-female ratio of 1.9 to 1, P<0.001). Conclusion: The incidence of congenital hypothyroidism in Lorestan Province is higher than the national average. Given the importance of early diagnosis of this disease, it is essential to educate mothers about the need to participate in the screening program promptly. |
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| Keywords: Screening, Congenital hypothyroidism, Risk factors, TSH |
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Full-Text [PDF 1056 kb]
(65 Downloads)
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Type of Study: Original |
Subject:
Endocrinology
Received: 2025/08/7 | Accepted: 2025/11/2 | Published: 2026/04/30
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