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The Levels of Follicle Stimulating Hormone in Men with Metabolic Syndrome: A Systematic Review and Meta-analysis
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M Saei Ghare Naz    , F Rashidi , Sh Amirshekari , F Ramezani Tehrani |
| Reproductive Endocrinology Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, , saeigarenaz@gmail.com |
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Abstract: (1 Views) |
Introduction: Metabolic syndrome is one of the chronic disorders that is increasing in men. Several factors are associated with the occurrence of this syndrome. Follicle-stimulating hormone has been investigated as a factor in male fertility in recent studies. This meta-analysis study summarized previous studies in this field. Materials and Methods: This meta-analysis was conducted through a comprehensive search of the databases Scopus, PubMed, and Web of Science, up to June 2025. Related keywords were combined using Boolean operators. The Newcastle Ottawa tool was used for quality assessment. The meta-analysis of studies reporting the mean and standard deviation of FSH was calculated as a Standardized Mean Difference (SMD) with 95% confidence intervals. Heterogeneity among studies was assessed using I² and Q statistics. Results: In this study, 12 studies were included in the analysis after screening from 2441 identified articles. In total, 7794 people were included, of whom 1101 had metabolic syndrome, and 6693 did not have metabolic syndrome. The results showed that the standardized mean follicle-stimulating hormone level in the affected group was significantly lower than that in the unaffected group. (SMD: -0.649; CI%.:-1.130 -0.168, p=0.008). Conclusion: The present study provides evidence of an association between FSH levels and metabolic syndrome in men, suggesting a role for FSH in metabolic diseases. However, due to heterogeneity of studies and methodological limitations, interpretation of the results should be done with caution.
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| Keywords: Metabolic syndrome, Follicle—stimulating hormone (FSH), Men |
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Full-Text [PDF 1059 kb]
(1 Downloads)
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Type of Study: Review |
Subject:
Endocrinology
Received: 2025/08/4 | Accepted: 2025/10/19 | Published: 2025/03/30
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