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The Effect of Eight Weeks of High-intensity Interval Training, Resistance Training, and Artichoke Extract Consumption on Sirtuin 1 Levels and Some Liver Enzymes in Patients with Nonalcoholic Fatty Liver Disease: a Clinical Trial Study
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Z Samiei    , S Shamlou-Kazemi , A Hemmati-Afif |
| Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamadan, Iran, , saeidshamlou9092@gmail.com |
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Abstract: (138 Views) |
Introduction: Due to decreased estrogen secretion, postmenopausal women are more susceptible to various diseases, including nonalcoholic fatty liver disease (NAFLD). This study investigated the effect of high-intensity interval training (HIIT), resistance training, and artichoke extract consumptionon serum levels of sirtuin 1 and liver enzymes in postmenopausal women with NAFLD. Materials and Methods: This study was conducted as a clinical trial in 60 postmenopausal women aged 50 to 65 years with nonalcoholic fatty liver disease, which included four groups of 15 people (high-intensity interval training, resistance training, artichoke extract consumption, and control). The interval training and resistance training protocol consisted of 8 weeks and three sessions per week. Artichoke extract was also used twice daily. Blood Factors were measured before and after the last training session. The data was analyzed by a paired t-test and two-way analysis of variance at P≤0.05 level. Results: The results showed a significant difference in the HIIT, resistance training and extract consumption groups compared to the pre-test in sirtuin 1 levels (P<0.001) and liver enzymes Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (P<0.001), while in the control group, no significant difference was observed in sirtuin 1 levels (P=0.250) and liver enzymes AST (P=0.270) and ALT (P=0.340). In the post-test, there was also a significant difference between the levels of Sirtuin 1 in HIIT group and the extract group (P<0.001). Conclusion: Periodic high-intensity resistance exercises and the consumption of artichoke extract positively affect the levels of liver enzymes and sirtuin-1 in people with nonalcoholic fatty liver disease. |
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| Keywords: Nonalcoholic fatty liver, High-intensity interval training, Resistance training, Artichoke, Sirtuin1 |
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Full-Text [PDF 1011 kb]
(49 Downloads)
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Type of Study: Original |
Subject:
Exercise
Received: 2025/01/2 | Accepted: 2025/03/15 | Published: 2025/03/30
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