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The Effect of Resistance Training on Inflammatory Factors TNF-α, CRP and IL-6 in Individuals with Chronic Kidney Disease: A Systematic Review and Meta-analysis
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M Khalafi    , F Almasi , M Aghaeinejad , A Qanbarpoor Nosrati , F Ghasemi |
| Department Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran, , Mousa.khalafi@kashanu.ac.ir |
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Abstract: (361 Views) |
Introduction: This meta-analysis investigates the effect of resistance training on inflammatory markers in individuals with chronic kidney disease (CKD). Materials and Methods: A comprehensive search was conducted in PubMed, Web of Science, Scopus, Google Scholar, Magiran, and NoorMags databases for English and Persian articles published until December 2023. The inclusion criteria for the present meta-analysis included 1) human research with chronic kidney disease subjects, 2) resistance training against the control group, 3) randomized controlled trials (RCT), and 4) measurement of inflammatory factors including TNF-α, CRP, and IL-6. To determine the effect size of the effect of exercise training against the control group on inflammatory markers on TNF-α, CRP, and IL-6, standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated. Results: Twelve studies, including 908 subjects, were included in the present meta-analysis. The results showed that resistance training significantly reduced TNF-α [SMD=-0.82 (Cl:-1.33 to -0.32), P=0.001], CRP [SMD=-0.70 (Cl:-0.07 to -1.32), P=0.02], and IL-6 [SMD=-0.58 (Cl:-0.28 to -0.89), P=0.001]. Conclusion: Resistance training may improve chronic inflammation by reducing IL-6, TNF-α and CRP in patients with CKD. |
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| Keywords: Resistance training, Inflammation, C-reactive protein, Interleukin-6, Tumor necrosis factor-alpha, Chronic kidney disease |
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Full-Text [PDF 1627 kb]
(141 Downloads)
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Type of Study: Review |
Subject:
Exercise
Received: 2024/11/16 | Accepted: 2025/02/15 | Published: 2025/03/30
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