[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
:: Volume 7, Issue 3 (9-2005) ::
2005, 7(3): 213-216 Back to browse issues page
The study of Angiogenesis in Malignant Thyroid neoplasms with immunohistochemistry method
SM Tavangar , SR Hojjati, B Larijani
, tavangar@ams.ac.ir
Abstract:   (20141 Views)
Introduction: Thyroid gland cancers are among the common cancers of endocrine glands in which the role of angiogenesis has not been clearly identified and more research seems necessary. Angiogenesis is an essential factor for growth, viabitily and extension of numerous cancers. The major goal of this research is to investigate the role of angiogenesis in malignant thyroid tumors and its relation with clinical and microscopic findings. Materials and methods: In a descriptive study, 205 paraffin blocks of malignant thyroid lesions were stained with factor 8 by the immunohistochemistry method (avidin-biotin peroxidase). Microvessels in 3 locations having more small vessels were counted, and the mean of microvessels for each case was calculated. Results: Mean vascular counts were 30.9 in papillary carcinoma (Standard Deviation=11.6) (avidin-bioten peroxidase) 35.7 in medullary carcinoma (Standard Deviation=20.4) 29.5 in follicular carcinoma (Standard Deviation=16.0) and 34.0 in anaplastic carcinoma (Standard Deviation=8.9) these results demonstrate that there is no statistical relationship with regard to microvessel count between the aforementioned groups (p value = 0.263). Conclusion: There is no significant difference in regard to angiogenesis between the malignant thyroid tumors studied and there is no statistically significant relationship between angiogenesis and microscopic findings (capsular invasion, vascular invasion and lymph node involvement) as well. This study reveals that in sharp contrast to many other common cancers, the role of angiogenesis in thyroid cancers is not so important and further studies for confirmation of this result are necessary.
Keywords: Angiogenesis, Thyroid, Maligant tumors, Immunohistochemistry
Full-Text [PDF 153 kb]   (1919 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2007/02/8
Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Tavangar S, Hojjati S, Larijani B. The study of Angiogenesis in Malignant Thyroid neoplasms with immunohistochemistry method. Iranian Journal of Endocrinology and Metabolism. 2005; 7 (3) :213-216
URL: http://ijem.sbmu.ac.ir/article-1-319-en.html


Volume 7, Issue 3 (9-2005) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.06 seconds with 33 queries by YEKTAWEB 3991